| Literature DB >> 20392439 |
Luning Shao1, Ting Li, Xiaoning Mo, Otto Majdic, Yanfei Zhang, Maria Seyerl, Catharina Schrauf, Dalong Ma, Johannes Stöckl, Wenling Han.
Abstract
Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells. In the present study, we showed that CKLF1 was highly expressed in monocytes. During differentiation from monocytes to immature DCs, CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated. Two peptides of CKLF1, C19 and C27, stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-gamma production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86. Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs. Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20392439 DOI： 10.1016/j.cellimm.2010.03.015
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868