OBJECTIVE: To assess and compare the sensitivity to change of the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) with that of other primary Sjögren's syndrome (SS) disease activity indexes. METHODS: We abstracted 96 patient profiles, including data on 3 successive visits (visits 1-3), from the medical charts of patients with primary SS. Patient profiles were scored with the ESSDAI, SS Disease Activity Index (SSDAI), and Sjögren's Systemic Clinical Activity Index (SCAI). Thirty-nine experts assessed 5 profiles for whether disease activity had improved, worsened, or remained stable at visits 2 and 3. RESULTS: For improved patients, the standardized response means (SRMs) for all scores did not differ, and ranged from -1.08 to -1.38 between visits 1 and 2 and from -0.50 to -0.76 between visits 2 and 3. For patients with worsened activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were +0.46 and +1.10 for the ESSDAI, -0.03 and +0.79 for the SSDAI, and +0.17 and +1.02 for the SCAI, respectively. For patients with stable activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were 0.00 and -0.13 for the ESSDAI, -0.44 and -0.11 for the SSDAI, and -0.36 and +0.34 for the SCAI, respectively. CONCLUSION: For patients with improved activity, the 3 disease activity indexes showed similar, large sensitivity to change. However, the ESSDAI seemed to detect changes in activity more accurately than other disease activity indexes. Notably, for patients with stable activity, the ESSDAI did not show erroneous improvement.
OBJECTIVE: To assess and compare the sensitivity to change of the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) with that of other primary Sjögren's syndrome (SS) disease activity indexes. METHODS: We abstracted 96 patient profiles, including data on 3 successive visits (visits 1-3), from the medical charts of patients with primary SS. Patient profiles were scored with the ESSDAI, SS Disease Activity Index (SSDAI), and Sjögren's Systemic Clinical Activity Index (SCAI). Thirty-nine experts assessed 5 profiles for whether disease activity had improved, worsened, or remained stable at visits 2 and 3. RESULTS: For improved patients, the standardized response means (SRMs) for all scores did not differ, and ranged from -1.08 to -1.38 between visits 1 and 2 and from -0.50 to -0.76 between visits 2 and 3. For patients with worsened activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were +0.46 and +1.10 for the ESSDAI, -0.03 and +0.79 for the SSDAI, and +0.17 and +1.02 for the SCAI, respectively. For patients with stable activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were 0.00 and -0.13 for the ESSDAI, -0.44 and -0.11 for the SSDAI, and -0.36 and +0.34 for the SCAI, respectively. CONCLUSION: For patients with improved activity, the 3 disease activity indexes showed similar, large sensitivity to change. However, the ESSDAI seemed to detect changes in activity more accurately than other disease activity indexes. Notably, for patients with stable activity, the ESSDAI did not show erroneous improvement.
Authors: Caroline H Shiboski; Stephen C Shiboski; Raphaèle Seror; Lindsey A Criswell; Marc Labetoulle; Thomas M Lietman; Astrid Rasmussen; Hal Scofield; Claudio Vitali; Simon J Bowman; Xavier Mariette Journal: Arthritis Rheumatol Date: 2016-10-26 Impact factor: 10.995
Authors: Raphaèle Seror; Simon J Bowman; Pilar Brito-Zeron; Elke Theander; Hendrika Bootsma; Athanasios Tzioufas; Jacques-Eric Gottenberg; Manel Ramos-Casals; Thomas Dörner; Philippe Ravaud; Claudio Vitali; Xavier Mariette; Karsten Asmussen; Soren Jacobsen; Elena Bartoloni; Roberto Gerli; Johannes Wj Bijlsma; Aike A Kruize; Stefano Bombardieri; Arthur Bookman; Cees Kallenberg; Petra Meiners; Johan G Brun; Roland Jonsson; Roberto Caporali; Steven Carsons; Salvatore De Vita; Nicoletta Del Papa; Valerie Devauchelle; Alain Saraux; Anne-Laure Fauchais; Jean Sibilia; Eric Hachulla; Gabor Illei; David Isenberg; Adrian Jones; Menelaos Manoussakis; Thomas Mandl; Lennart Jacobsson; Frederic Demoulins; Carlomaurizio Montecucco; Wan-Fai Ng; Sumusu Nishiyama; Roald Omdal; Ann Parke; Sonja Praprotnik; Matjia Tomsic; Elizabeth Price; Hal Scofield; Kathy L Sivils; Josef Smolen; Roser Solans Laqué; Serge Steinfeld; Nurhan Sutcliffe; Takayuki Sumida; Guido Valesini; Valeria Valim; Frederick B Vivino; Cristina Vollenweider Journal: RMD Open Date: 2015-02-20