BACKGROUND: The inositol glycans (IGs) are glycolipid-derived carbohydrates produced by insulin-sensitive cells in response to insulin treatment. IGs exhibit an array of insulin-like activities including stimulation of lipogenesis, glucose transport and glycogen synthesis, suggesting that they may be involved in insulin signal transduction. However, because the natural IGs are structurally heterogeneous and difficult to purify to homogeneity, an understanding of the relationship between structure and biological activity has relied principally on synthetic IGs of defined structure. DISCUSSION: This article briefly describes what is known about the role of IGs in signal transduction and reviews the specific biological activities of the structurally defined IGs synthesized and tested to date. CONCLUSION: A pharmacophore for IG activity begins to emerge from the reviewed data and the structural elements necessary for activity are summarized.
BACKGROUND: The inositol glycans (IGs) are glycolipid-derived carbohydrates produced by insulin-sensitive cells in response to insulin treatment. IGs exhibit an array of insulin-like activities including stimulation of lipogenesis, glucose transport and glycogen synthesis, suggesting that they may be involved in insulin signal transduction. However, because the natural IGs are structurally heterogeneous and difficult to purify to homogeneity, an understanding of the relationship between structure and biological activity has relied principally on synthetic IGs of defined structure. DISCUSSION: This article briefly describes what is known about the role of IGs in signal transduction and reviews the specific biological activities of the structurally defined IGs synthesized and tested to date. CONCLUSION: A pharmacophore for IG activity begins to emerge from the reviewed data and the structural elements necessary for activity are summarized.
Authors: Faiyaz Ahmad; Rebecka Lindh; Yan Tang; Marie Weston; Eva Degerman; Vincent C Manganiello Journal: Biochem J Date: 2007-06-01 Impact factor: 3.857
Authors: J Larner; L C Huang; C F Schwartz; A S Oswald; T Y Shen; M Kinter; G Z Tang; K Zeller Journal: Biochem Biophys Res Commun Date: 1988-03-30 Impact factor: 3.575
Authors: Dina Medina-Vera; Juan Antonio Navarro; Rubén Tovar; Cristina Rosell-Valle; Alfonso Gutiérrez-Adan; Juan Carlos Ledesma; Carlos Sanjuan; Francisco Javier Pavón; Elena Baixeras; Fernando Rodríguez de Fonseca; Juan Decara Journal: Nutrients Date: 2021-06-30 Impact factor: 5.717