Literature DB >> 20388920

Saturated fatty acids enhance osteoclast survival.

So-Ra Oh1, Ok-Joo Sul, Youn-Young Kim, Hye-Jin Kim, Rina Yu, Jae-Hee Suh, Hye-Seon Choi.   

Abstract

Hyperlipidemia and marrow fat are associated with lowering bone density in vivo, suggesting that lipid contributes to bone loss. Using bone marrow-derived macrophages, we investigated the effect of saturated fatty acids (SFA) on osteoclastogenesis. The level of free fatty acids and adiposity in bone marrow was significantly elevated in obese mice. SFA increased osteoclast (OC) survival by preventing apoptosis. SFA caused the production of MIP-1alpha and led to activation of nuclear factor (NF)-kappaB in the OC. The absence of Toll-like receptor 4 (TLR4) or myeloid differentiation factor 88 (MyD88) abolished the survival effect of SFA on OC.

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Year:  2010        PMID： 20388920      PMCID： PMC2853456          DOI： 10.1194/jlr.M800626

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  37 in total

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7.  Triglyceride metabolism in bone tissue is associated with osteoblast and osteoclast differentiation: a gene expression study.

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