Anji T Yetman1, Brian W McCrindle. 1. University of Utah, Primary Children's Medical Center, Salt Lake City, 84108, USA. angela.yetman@imail.org
Abstract
BACKGROUND: Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. OBJECTIVE: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. METHODS: Fifty outpatients (30 female) with a mean (+/- SD) age of 38+/-13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kgm2), overweight (BMI 25 kgm2 to 29.9 kgm2) or obese (BMI 30 kgm2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. RESULTS: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4+/-7.4 kgm2, with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hypertension in 13 (26%) and hyperlipidemia in 19 (38%) patients. Adverse clinical outcome was present in 27 (54%) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS: Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.
BACKGROUND:Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. OBJECTIVE: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. METHODS: Fifty outpatients (30 female) with a mean (+/- SD) age of 38+/-13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kgm2), overweight (BMI 25 kgm2 to 29.9 kgm2) or obese (BMI 30 kgm2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. RESULTS: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4+/-7.4 kgm2, with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hypertension in 13 (26%) and hyperlipidemia in 19 (38%) patients. Adverse clinical outcome was present in 27 (54%) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS:Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.
Authors: D I Silverman; J Gray; M J Roman; A Bridges; K Burton; M Boxer; R B Devereux; P Tsipouras Journal: J Am Coll Cardiol Date: 1995-10 Impact factor: 24.094
Authors: Matthew J Eagleton; Nicole Ballard; Erin Lynch; Sunita D Srivastava; Gilbert R Upchurch; James C Stanley Journal: J Surg Res Date: 2006-05-22 Impact factor: 2.192
Authors: Henry C McGill; C Alex McMahan; Edward E Herderick; Arthur W Zieske; Gray T Malcom; Richard E Tracy; Jack P Strong Journal: Circulation Date: 2002-06-11 Impact factor: 29.690
Authors: D I Silverman; K J Burton; J Gray; M S Bosner; N T Kouchoukos; M J Roman; M Boxer; R B Devereux; P Tsipouras Journal: Am J Cardiol Date: 1995-01-15 Impact factor: 2.778
Authors: Laura Muiño-Mosquera; Fré Bauters; Karlien Dhondt; Hans De Wilde; Luc Jordaens; Katya De Groote; Daniel De Wolf; Katrien Hertegonne; Julie De Backer Journal: Mol Genet Genomic Med Date: 2019-06-27 Impact factor: 2.183
Authors: Christine H Attenhofer Jost; Matthias Greutmann; Heidi M Connolly; Roland Weber; Marianne Rohrbach; Angela Oxenius; Oliver Kretschmar; Thomas F Luscher; Gabor Matyas Journal: Curr Cardiol Rev Date: 2014-05
Authors: Carmel Ashur; Elizabeth Norton; Linda Farhat; Anna Conlon; Cristen Willer; James B Froehlich; David J Pinsky; Karen M Kim; Shinichi Fukuhara; Michael G Deeb; Himanshu Patel; Kim A Eagle; Bo Yang; Marion A Hofmann Bowman Journal: Sci Rep Date: 2020-03-13 Impact factor: 4.379