BACKGROUND: The limbic system-associated membrane protein (LAMP) promotes development of neurons of limbic origin. We have previously shown that genetic deletion of LAMP results in heightened reactivity to novelty and reduced anxiety-like behaviors in mice. Here, we demonstrate a critical role of LAMP in hippocampal-dependent synaptic physiology and behavior. METHODS: We tested spatial memory performance, hippocampal synaptic plasticity, and stress-related modalities in Lsamp(-/-) mice and their littermate control mice. RESULTS: Lsamp(-/-) mice exhibit a pronounced deficit in spatial memory acquisition and poorly sustained CA1 long-term potentiation. We found reduced expression of mineralocorticoid receptor (MR) transcripts in the hippocampus and reduction in the corticosterone-induced, MR-mediated nongenomic modulatory effects on CA1 synaptic transmission. Importantly, the impaired long-term potentiation in Lsamp(-/-) mice can be rescued by stress-like levels of corticosterone in a MR-dependent manner. CONCLUSIONS: Our study reveals a novel functional relationship between a cell adhesion molecule enriched in developing limbic circuits, glucocorticoid receptors, and cognitive functioning. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
BACKGROUND: The limbic system-associated membrane protein (LAMP) promotes development of neurons of limbic origin. We have previously shown that genetic deletion of LAMP results in heightened reactivity to novelty and reduced anxiety-like behaviors in mice. Here, we demonstrate a critical role of LAMP in hippocampal-dependent synaptic physiology and behavior. METHODS: We tested spatial memory performance, hippocampal synaptic plasticity, and stress-related modalities in Lsamp(-/-) mice and their littermate control mice. RESULTS:Lsamp(-/-) mice exhibit a pronounced deficit in spatial memory acquisition and poorly sustained CA1 long-term potentiation. We found reduced expression of mineralocorticoid receptor (MR) transcripts in the hippocampus and reduction in the corticosterone-induced, MR-mediated nongenomic modulatory effects on CA1 synaptic transmission. Importantly, the impaired long-term potentiation in Lsamp(-/-) mice can be rescued by stress-like levels of corticosterone in a MR-dependent manner. CONCLUSIONS: Our study reveals a novel functional relationship between a cell adhesion molecule enriched in developing limbic circuits, glucocorticoid receptors, and cognitive functioning. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Authors: Orlando D Gil; Li Zhang; Suzanne Chen; Y Q Ren; Aurea Pimenta; George Zanazzi; Dean Hillman; Pat Levitt; James L Salzer Journal: J Neurobiol Date: 2002-06-05
Authors: Christian Otte; Katja Wingenfeld; Linn K Kuehl; Michael Kaczmarczyk; Steffen Richter; Arnim Quante; Francesca Regen; Malek Bajbouj; Frank Zimmermann-Viehoff; Klaus Wiedemann; Kim Hinkelmann Journal: Neuropsychopharmacology Date: 2014-07-18 Impact factor: 7.853
Authors: K Koido; T Traks; R Balõtšev; T Eller; A Must; S Koks; E Maron; I Tõru; J Shlik; V Vasar; E Vasar Journal: Transl Psychiatry Date: 2012-08-14 Impact factor: 6.222
Authors: Shenfeng Qiu; Shujun Luo; Oleg Evgrafov; Robin Li; Gary P Schroth; Pat Levitt; James A Knowles; Kai Wang Journal: Front Genet Date: 2012-07-06 Impact factor: 4.599
Authors: Angela W S Lee; Heidi Hengstler; Kathrin Schwald; Mauricio Berriel-Diaz; Desirée Loreth; Matthias Kirsch; Oliver Kretz; Carola A Haas; Martin Hrabě de Angelis; Stephan Herzig; Thomas Brümmendorf; Martin Klingenspor; Fritz G Rathjen; Jan Rozman; George Nicholson; Roger D Cox; Michael K E Schäfer Journal: PLoS One Date: 2012-07-23 Impact factor: 3.240