Literature DB >> 20385355

What's so special about RB?

Christin E Burd1, Norman E Sharpless.   

Abstract

RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20385355      PMCID： PMC3725986          DOI： 10.1016/j.ccr.2010.03.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.

Authors:  Kevin Haigis; Julien Sage; Jon Glickman; Sarah Shafer; Tyler Jacks
Journal:  J Biol Chem       Date:  2005-10-28       Impact factor: 5.157

2.  Kinase-independent function of cyclin E.

Authors:  Yan Geng; Young-Mi Lee; Markus Welcker; Jherek Swanger; Agnieszka Zagozdzon; Joel D Winer; James M Roberts; Philipp Kaldis; Bruce E Clurman; Piotr Sicinski
Journal:  Mol Cell       Date:  2007-01-12       Impact factor: 17.970

Review 3.  Cellular senescence: when bad things happen to good cells.

Authors:  Judith Campisi; Fabrizio d'Adda di Fagagna
Journal:  Nat Rev Mol Cell Biol       Date:  2007-09       Impact factor: 94.444

4.  Distinct roles for p107 and p130 in Rb-independent cellular senescence.

Authors:  Brian D Lehmann; Adam M Brooks; Matthew S Paine; William H Chappell; James A McCubrey; David M Terrian
Journal:  Cell Cycle       Date:  2008-03-07       Impact factor: 4.534

5.  Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.

Authors:  Christopher A Reed; Christopher N Mayhew; A Kathleen McClendon; Erik S Knudsen
Journal:  J Biol Chem       Date:  2009-11-02       Impact factor: 5.157

6.  pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

Authors:  R K Hurford; D Cobrinik; M H Lee; N Dyson
Journal:  Genes Dev       Date:  1997-06-01       Impact factor: 11.361

7.  Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

Authors:  Agustin Chicas; Xiaowo Wang; Chaolin Zhang; Mila McCurrach; Zhen Zhao; Ozlem Mert; Ross A Dickins; Masashi Narita; Michael Zhang; Scott W Lowe
Journal:  Cancer Cell       Date:  2010-04-13       Impact factor: 31.743

8.  Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts.

Authors:  R E Herrera; V P Sah; B O Williams; T P Mäkelä; R A Weinberg; T Jacks
Journal:  Mol Cell Biol       Date:  1996-05       Impact factor: 4.272

9.  Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters.

Authors:  Kristy R Stengel; Chellappagounder Thangavel; David A Solomon; Steve P Angus; Yi Zheng; Erik S Knudsen
Journal:  J Biol Chem       Date:  2009-03-11       Impact factor: 5.157

10.  Regulation of RB transcription in vivo by RB family members.

Authors:  Deborah L Burkhart; Lynn K Ngai; Caitlin M Roake; Patrick Viatour; Chellappagounder Thangavel; Victoria M Ho; Erik S Knudsen; Julien Sage
Journal:  Mol Cell Biol       Date:  2010-01-25       Impact factor: 4.272
  10 in total

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