Literature DB >> 20385233

A short practical approach to 24R,25-dihydroxyvitamin D3.

Daniel Nicoletti1, Carlos Gregorio, Antonio Mouriño, Miguel Maestro.   

Abstract

A synthesis of the vitamin D3 metabolite 24R,25-dihydroxyvitamin D3 (1) by Lythgoe's Wittig-Horner approach is described. The key step of the synthesis is the stereocontrolled introduction of the 24-hydroxyl group by a palladium(0)-induced [3,3]-sigmatropic rearrangement on a 22R-allylic acetate (7). Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20385233     DOI： 10.1016/j.jsbmb.2010.03.071

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  2 in total

1.  Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD.

Authors:  Martin Kaufmann; J Christopher Gallagher; Munro Peacock; Karl-Peter Schlingmann; Martin Konrad; Hector F DeLuca; Rita Sigueiro; Borja Lopez; Antonio Mourino; Miguel Maestro; René St-Arnaud; Joel S Finkelstein; Donald P Cooper; Glenville Jones
Journal:  J Clin Endocrinol Metab       Date:  2014-03-26       Impact factor: 5.958

2.  Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism.

Authors:  Fumihiro Kawagoe; Sayuri Mototani; Kaori Yasuda; Hiroki Mano; Toshiyuki Sakaki; Atsushi Kittaka
Journal:  Int J Mol Sci       Date:  2021-11-01       Impact factor: 5.923
  2 in total

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