BACKGROUND: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. METHODS: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). RESULTS: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. CONCLUSION: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity.
BACKGROUND: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. METHODS: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). RESULTS:AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. CONCLUSION: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity.
Authors: Dirk A E Dietz de Loos; Christine L Segboer; Artur Gevorgyan; Wytske J Fokkens Journal: Curr Allergy Asthma Rep Date: 2013-04 Impact factor: 4.806
Authors: Vicky Kritikos; David Price; Alberto Papi; Antonio Infantino; Björn Ställberg; Dermot Ryan; Federico Lavorini; Henry Chrystyn; John Haughney; Karin Lisspers; Kevin Gruffydd-Jones; Miguel Román Rodríguez; Svein Høegh Henrichsen; Thys van der Molen; Victoria Carter; Sinthia Bosnic-Anticevich Journal: J Asthma Allergy Date: 2020-10-06
Authors: Jean Bousqet; Filip Raciborski; Jean Bousquet; Andrzej Namysłowski; Edyta Krzych-Fałta; Aneta Tomaszewska; Barbara Piekarska; Piotr Samel-Kowalik; Artur Z Białoszewski; Artur Walkiewicz; Agnieszka Lipiec; Oksana Wojas; Krzysztof Samoliński; Anna Szylling; Wojciech Zieliński; Adam Sybilski; Aleksandra Grąbczewska; Bolesław Samoliński Journal: Clin Transl Allergy Date: 2019-02-11 Impact factor: 5.871
Authors: P W Hellings; B Pugin; G Mariën; C Bachert; C Breynaert; D M Bullens; J L Ceuppens; G Clement; T Cox; D Ebo; P Gevaert; S Halewyck; V Hox; K Ladha; R Jacobs; P Rombaux; R Schrijvers; K Speleman; X Van der Brempt; L Van Gerven; O Vanderveken; B Verhaeghe; K Vierstraete; S Vlaminck; J-B Watelet; J Bousquet; S F Seys Journal: Clin Transl Allergy Date: 2019-02-04 Impact factor: 5.871
Authors: Benedikt Fritzsching; Marco Contoli; Celeste Porsbjerg; Sarah Buchs; Julie Rask Larsen; Lisa Elliott; Mercedes Romano Rodriguez; Nick Freemantle Journal: Lancet Reg Health Eur Date: 2021-11-30
Authors: Justo Padilla; Mónica Uceda; Otto Ziegler; Felipe Lindo; Eder Herrera-Pérez; Luis Huicho Journal: Biomed Res Int Date: 2013-07-25 Impact factor: 3.411