Literature DB >> 20384500

Reduction of opioid side effects by prophylactic measures of palliative care team may result in improved quality of life.

Michiaki Myotoku1, Akiko Nakanishi, Miwa Kanematsu, Noriko Sakaguchi, Norio Hashimoto, Fumiko Koyama, Seiji Yamaguchi, Kenji Ikeda, Hiroki Konishi, Yoshihiko Hirotani.   

Abstract

PURPOSE: In February 2002, the palliative care team was established in Ikeda Municipal Hospital to improve palliative care. We investigated changes in the incidences of side effects related to opioids, and evaluated palliative care team activities.
METHODS: Regarding inpatients for whom narcotics were prescribed in our hospital in the years of 2002 (from October 1, 2002 until September 30, 2003), 2004 (from October 1, 2004 until September 30, 2005), and 2006 (from October 1, 2006 until September 30, 2007), we surveyed the rates at which laxatives or antiemetics were prescribed, frequency of defecation/its state before and after the start of narcotic therapy, frequency of nausea/vomiting, and dietary intake.
RESULTS: The proportions of patients in whom laxatives were simultaneously prescribed during opioid therapy in 2002, 2004, and 2006 were 43.5%, 78.7%, and 75.6%, respectively. The proportions of those in whom antiemetics were combined with opioids were 45.7%, 78.7%, and 78.0%, respectively. The incidences of constipation were 50.0%, 39.3%, and 37.8%, respectively. Those of nausea/vomiting were 30.4%, 21.3%, and 9.8%, respectively. Those of anorexia were 65.3%, 39.4%, and 15.4%, respectively.
CONCLUSIONS: These results suggest that palliative care team activities facilitated appropriate drug prescription during opioid therapy, reducing the appearance of side effects, with likelihood of improved quality of life.

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Year:  2010        PMID: 20384500     DOI: 10.1089/jpm.2009.0355

Source DB:  PubMed          Journal:  J Palliat Med        ISSN: 1557-7740            Impact factor:   2.947


  4 in total

Review 1.  Narcotic bowel syndrome and opioid-induced constipation.

Authors:  Eva Szigethy; Marc Schwartz; Douglas Drossman
Journal:  Curr Gastroenterol Rep       Date:  2014-10

2.  Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial.

Authors:  Anna Ozaki; Takaomi Kessoku; Kosuke Tanaka; Atsushi Yamamoto; Kota Takahashi; Yuma Takeda; Yuki Kasai; Michihiro Iwaki; Takashi Kobayashi; Tsutomu Yoshihara; Takayuki Kato; Akihiro Suzuki; Yasushi Honda; Yuji Ogawa; Akiko Fuyuki; Kento Imajo; Takuma Higurashi; Masato Yoneda; Masataka Taguri; Hiroto Ishiki; Noritoshi Kobayashi; Satoru Saito; Yasushi Ichikawa; Atsushi Nakajima
Journal:  Cancers (Basel)       Date:  2022-04-24       Impact factor: 6.575

3.  Reporting of "quality of life": a systematic review and quantitative analysis of research publications in palliative care journals.

Authors:  Senthil P Kumar
Journal:  Indian J Palliat Care       Date:  2012-01

4.  Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study.

Authors:  Anna Ozaki; Takaomi Kessoku; Michihiro Iwaki; Takashi Kobayashi; Tsutomu Yoshihara; Takayuki Kato; Yasushi Honda; Yuji Ogawa; Kento Imajo; Takuma Higurashi; Masato Yoneda; Masataka Taguri; Takeharu Yamanaka; Hiroto Ishiki; Noritoshi Kobayashi; Satoru Saito; Yasushi Ichikawa; Atsushi Nakajima
Journal:  Trials       Date:  2020-06-01       Impact factor: 2.728

  4 in total

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