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Literature DB >> 20384296

Dolabellane-type diterpenoids with antiprotozoan activity from a southwestern Caribbean gorgonian octocoral of the genus Eunicea.

Xiaomei Wei¹, Abimael D Rodríguez, Peter Baran, Raphael G Raptis.

Abstract

Ten new diterpenes, 1-10, having a dolabellane skeleton were isolated from a Colombian gorgonian coral of the genus Eunicea. Their structures, as well as those of known compounds 11-18, were determined on the basis of spectroscopic analysis and, in some instances, by chemical conversion and X-ray crystallographic analysis. The absolute structure of 7 was established by chemical conversion from 11, a co-occurring dolabellane congener of known absolute structure. Most of these diterpenoids showed antimalarial activity against the protozoan parasite Plasmodium falciparum.

Entities: CellLine Chemical Disease Species

Mesh：

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Year: 2010 PMID： 20384296 PMCID： PMC2878742 DOI： 10.1021/np100074r

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

11 in total

1. A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity.

Authors: Yolanda Corbett; Liuris Herrera; Jose Gonzalez; Luis Cubilla; Todd L Capson; Phyllis D Coley; Thomas A Kursar; Luz I Romero; Eduardo Ortega-Barria
Journal: Am J Trop Med Hyg Date: 2004-02 Impact factor: 2.345

2. Calyculatine: a new dolabellane diterpenoid from the marine sponge Eunicea calyculata.

Authors: Wei Xiang; Leng Chee Chang
Journal: Planta Med Date: 2006-05-31 Impact factor: 3.352

3. Malaria. Signs of drug resistance rattle experts, trigger bold plan.

Authors: Martin Enserink
Journal: Science Date: 2008-12-19 Impact factor: 47.728

4. Concise total syntheses of palominol, dolabellatrienone, beta-araneosene, and isoedunol via an enantioselective Diels-Alder macrobicyclization.

Authors: Scott A Snyder; E J Corey
Journal: J Am Chem Soc Date: 2006-01-25 Impact factor: 15.419

5. Artemisinin-resistant malaria in Asia.

Authors: Harald Noedl; Duong Socheat; Wichai Satimai
Journal: N Engl J Med Date: 2009-07-30 Impact factor: 91.245

6. Bioactive marine diterpenoids from Japanese soft coral of Clavularia sp.

Authors: K Mori; K Iguchi; N Yamada; Y Yamada; Y Inouye
Journal: Chem Pharm Bull (Tokyo) Date: 1988-08 Impact factor: 1.645

7. Additional dolabellane diterpenes from the Caribbean gorgonian octocoral Eunicea laciniata.

Authors: A D Rodríguez; E González; C González
Journal: J Nat Prod Date: 1995-02 Impact factor: 4.050

8. Mechanism-based antitumor screening of Caribbean marine organisms: isolation and structure determination of novel diterpenoids from the gorgonian Eunicea tourneforti.

Authors: M Govindan; G N Govindan; D G Kingston
Journal: J Nat Prod Date: 1995-08 Impact factor: 4.050

Review 9. Diterpenes from gorgonian corals.

Authors: Fabrice Berrue; Russell G Kerr
Journal: Nat Prod Rep Date: 2009-03-25 Impact factor: 13.423

10. The structure of palominol by interpretation of two-dimensional NMR shift correlation experiments: isolation and structure determination of isopalominol.

Authors: A D Rodríguez; A L Acosta; H Dhasmana
Journal: J Nat Prod Date: 1993-10 Impact factor: 4.050

14 in total

1. Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides.

Authors: Carlos Jiménez-Romero; Idelisse Ortiz; Jan Vicente; Brunilda Vera; Abimael D Rodríguez; Sangkil Nam; Richard Jove
Journal: J Nat Prod Date: 2010-10-05 Impact factor: 4.050

2. Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean sea sponge Neopetrosia proxima.

Authors: Xiaomei Wei; Karinel Nieves; Abimael D Rodríguez
Journal: Bioorg Med Chem Lett Date: 2010-07-24 Impact factor: 2.823

Review 3. Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors: Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal: Comp Biochem Physiol C Toxicol Pharmacol Date: 2007-02-09 Impact factor: 3.228

4. Conformational effects and stereocontrol in synthesis studies of medium-ring dolabellane carbocycles.

Authors: David R Williams; Leslie A Robinson; Seth A Bawel
Journal: Tetrahedron Lett Date: 2015-06-03 Impact factor: 2.415

Review 5. The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules.

Authors: Katharine R Watts; Karen Tenney; Phillip Crews
Journal: Curr Opin Biotechnol Date: 2010-10-16 Impact factor: 9.740

Review 6. Cnidarians as a potential source of antiparasitic drugs.

Authors: Osama Mostafa; Mohammed Al-Shehri; Mahmoud Moustafa; Ahmed Al-Emam
Journal: Parasitol Res Date: 2021-11-29 Impact factor: 2.289

7. Pharmacological evaluation of the semi-purified fractions from the soft coral Eunicella singularis and isolation of pure compounds.

Authors: Monia Deghrigue; Carmen Festa; Lotfi Ghribi; Maria Valeria D'auria; Simona de Marino; Hichem Ben Jannet; Rafik Ben Said; Abderrahman Bouraoui
Journal: Daru Date: 2014-09-10 Impact factor: 3.117