Environmental factors in cancer: trichloroethylene and related solvents: science, regulation, and cancer prevention.

In summary, I have used the case of TCE exposure as an example of: (1) The importance of population-based research to identify and characterize possible environmental risk factors for cancer, and the need for a greater emphasis and proportional increase in public funding of research on prevention as compared to treatment. We need to understand these risks better, and use this information to drive effective public health prevention actions. (2) The imposition of strong restrictions on requests by bona fide researchers for access to data as a barrier to research that could be used to help resolve some of the most controversial issues in TCE epidemiology, in particular, and environmental risks in general, especially access to individual level data including data of event and location of residence. Researchers need ready access these data to more accurately characterize environmental exposures, diseases and their possible associations, and to help develop more effective public health preventive actions, although they should also protect confidentiality. (3) The need for more accurate and comprehensive biomarkers of exposure and disease to better assess possible associations between environmental and occupational exposures and disease; (4) The role of non-scientific concerns in limiting regulatory and advisory agencies in the reevaluation of their positions relative to preventing or lowering allowable exposures to TCE, in light of the growing body of evidence on the possible carcinogenicity of a compound still widely in use, to which many workers, and substantial segments of the general public, are exposed.