Literature DB >> 20383759

PARP and PARG inhibitors--new therapeutic targets in cancer treatment.

Nilufer Jasmine Selimah Fauzee1, Juan Pan, Ya-lan Wang.   

Abstract

Today, the number of cancer patients throughout the world is increasing alarmingly and as per the World Health Organisation (WHO) data and statistics the prediction for the year 2020 will be 15 million new cases as compared to only 10 million cases in year 2000 leaving us dumbfounded. A lot of effort has been put in by researchers and scientists over decades to find drugs helpful in the treatment of cancers for the benefit of patients--the latest being the Poly ADP-ribose polymerase (PARP) and the Poly ADP-ribose glycohydrolase (PARG) inhibitors. This review highlights their mechanism of action under the rationale of their use and current development in the field of cancer.

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Year:  2010        PMID： 20383759     DOI： 10.1007/s12253-010-9266-6

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  103 in total

1.  Oxidative stress inhibits apoptosis in human lymphoma cells.

Authors:  Y J Lee; E Shacter
Journal:  J Biol Chem       Date:  1999-07-09       Impact factor: 5.157

2.  Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster.

Authors:  Shuji Hanai; Masayuki Kanai; Sayaka Ohashi; Keiji Okamoto; Mitsunori Yamada; Hitoshi Takahashi; Masanao Miwa
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-15       Impact factor: 11.205

3.  Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.

Authors:  Krisztina Kovacs; Ambrus Toth; Peter Deres; Tamas Kalai; Kalman Hideg; Ferenc Gallyas; Balazs Sumegi
Journal:  Biochem Pharmacol       Date:  2005-12-06       Impact factor: 5.858

4.  Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide.

Authors:  Lucio Tentori; Carlo Leonetti; Marco Scarsella; Alessia Muzi; Matteo Vergati; Olindo Forini; Pedro Miguel Lacal; Federica Ruffini; Barry Gold; Weixing Li; Jie Zhang; Grazia Graziani
Journal:  Eur J Cancer       Date:  2005-11-08       Impact factor: 9.162

5.  Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.

Authors:  T Nozaki; M Masutani; M Watanabe; T Ochiya; F Hasegawa; H Nakagama; H Suzuki; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

6.  Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats.

Authors:  J P Roesner; D A Vagts; T Iber; C Eipel; B Vollmar; G F E Nöldge-Schomburg
Journal:  Intensive Care Med       Date:  2006-08-23       Impact factor: 17.440

7.  Modulation of poly(ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells.

Authors:  M Bhatia; J B Kirkland; K A Meckling-Gill
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

8.  Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

Authors:  Christopher R Calabrese; Michael A Batey; Huw D Thomas; Barbara W Durkacz; Lan-Zhen Wang; Suzanne Kyle; Donald Skalitzky; Janke Li; Catherine Zhang; Theodore Boritzki; Karen Maegley; Alan H Calvert; Zdenek Hostomsky; David R Newell; Nicola J Curtin
Journal:  Clin Cancer Res       Date:  2003-07       Impact factor: 12.531

9.  Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34.

Authors:  Anastasia Pyriochou; Gabor Olah; Edwin A Deitch; Csaba Szabó; Andreas Papapetropoulos
Journal:  Int J Mol Med       Date:  2008-07       Impact factor: 4.101

10.  Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.

Authors:  Ming Li; Michael D Threadgill; Yalan Wang; Li Cai; Xiao Lin
Journal:  Pathobiology       Date:  2009-05-19       Impact factor: 4.342
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  14 in total

Review 1.  Insight into the machinery that oils chromatin dynamics.

Authors:  Roni H G Wright; Narcis Fernandez-Fuentes; Baldomero Oliva; Miguel Beato
Journal:  Nucleus       Date:  2016-11-28       Impact factor: 4.197

2.  Hydrogen peroxide modulates synaptic transmission in ventral horn neurons of the rat spinal cord.

Authors:  Masayuki Ohashi; Toru Hirano; Kei Watanabe; Keiichi Katsumi; Nobuko Ohashi; Hiroshi Baba; Naoto Endo; Tatsuro Kohno
Journal:  J Physiol       Date:  2015-12-07       Impact factor: 5.182

3.  Silencing Poly (ADP-Ribose) glycohydrolase (PARG) expression inhibits growth of human colon cancer cells in vitro via PI3K/Akt/NFκ-B pathway.

Authors:  Nilufer Jasmine Selimah Fauzee; Qiaozhuan Li; Ya-Lan Wang; Juan Pan
Journal:  Pathol Oncol Res       Date:  2011-06-30       Impact factor: 3.201

4.  The poly (ADP-ribose) polymerase inhibitor rucaparib suppresses proliferation and serves as an effective radiosensitizer in cervical cancer.

Authors:  Mei Tang; Qiuli Liu; Leyuan Zhou; Ling Chen; Xueqing Yang; Jinjin Yu; Yuan Wang; Haifeng Qiu
Journal:  Invest New Drugs       Date:  2018-06-06       Impact factor: 3.850

Review 5.  TRPM2: a multifunctional ion channel for calcium signalling.

Authors:  Adriana Sumoza-Toledo; Reinhold Penner
Journal:  J Physiol       Date:  2010-12-06       Impact factor: 5.182

6.  Novel hydrophilic docetaxel (CQMU-0519) analogue inhibits proliferation and induces apoptosis in human A549 lung, SKVO3 ovarian and MCF7 breast carcinoma cell lines.

Authors:  N J S Fauzee; Y-L Wang; Z Dong; Q-G Li; T Wang; M T Mandarry; L Xu; J Pan
Journal:  Cell Prolif       Date:  2012-06-05       Impact factor: 6.831

7.  Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.

Authors:  Xibao Liu; Ana Cotrim; Leyla Teos; Changyu Zheng; William Swaim; James Mitchell; Yasuo Mori; Indu Ambudkar
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

8.  Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin.

Authors:  Seon-Gyeong Lee; Namwoo Kim; Su-Min Kim; In Bae Park; Hyejin Kim; Shinseog Kim; Byung-Gyu Kim; Jung Me Hwang; In-Joon Baek; Anton Gartner; Jun Hong Park; Kyungjae Myung
Journal:  EMBO Rep       Date:  2020-10-01       Impact factor: 8.807

9.  Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.

Authors:  Julie A Tucker; Neil Bennett; Claire Brassington; Stephen T Durant; Giles Hassall; Geoff Holdgate; Mark McAlister; J Willem M Nissink; Caroline Truman; Martin Watson
Journal:  PLoS One       Date:  2012-12-10       Impact factor: 3.240

Review 10.  Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.

Authors:  Julio Morales; Longshan Li; Farjana J Fattah; Ying Dong; Erik A Bey; Malina Patel; Jinming Gao; David A Boothman
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2014       Impact factor: 1.406
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