Prevention of postoperative peritoneal adhesions.

Adhesions are bands of tissue that connect organs together. It is frequently reported after surgery and remains a major problem for health and society. Efforts to prevent or reduce peritoneal adhesions mostly have been unsuccessful, hindered by their empirical basis, lack of good predictive animal models and complexity of adhesion pathogenesis. Although a good surgical technique is a crucial part of adhesion prevention, the technique alone cannot effectively eliminate the adhesions. Thus, there remains a room for further research. A comprehensive literature review of published experimental and clinical studies of adhesion prevention was carried out at the University of Bristol electronic library (MetaLib) with cross-search of seven different medical databases (AMED-Allied and Complementary Medicine Database, BIOSIS Previews on Web of Knowledge, Cochrane Library, Embase and Medline on Web of Knowledge, OvidSP and PubMed) by using key words (peritoneal adhesions, postoperative adhesions, prevention) to explore the progress in different surgical strategies and adjuvant materials used to prevent adhesions formation and reformation. By the end of the study, recommendations formulated for surgeons to be followed during the operations to prevent, as much as possible, the postoperative adhesions. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.