BACKGROUND & AIMS: While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke. METHODS: Prospective cohort of 21,078 participants from the Physicians' Health Study (1982-2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox's proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts. RESULTS: During a mean follow up of 21.1 years, 1424 incident cases of stroke occurred (219 hemorrhagic, 1189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable-adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts <1, 1, 2-4, 5-6, and ≥7 times/week were 1.13 (0.78-1.62), 1.05 (0.70-1.58), 0.49 (0.27-0.89), 1.50 (0.79-2.84), and 1.84 (0.95-3.57), respectively (p for quadratic trend 0.12). CONCLUSIONS: Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted. Published by Elsevier Ltd.
RCT Entities:
BACKGROUND & AIMS: While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke. METHODS: Prospective cohort of 21,078 participants from the Physicians' Health Study (1982-2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox's proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts. RESULTS: During a mean follow up of 21.1 years, 1424 incident cases of stroke occurred (219 hemorrhagic, 1189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable-adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts <1, 1, 2-4, 5-6, and ≥7 times/week were 1.13 (0.78-1.62), 1.05 (0.70-1.58), 0.49 (0.27-0.89), 1.50 (0.79-2.84), and 1.84 (0.95-3.57), respectively (p for quadratic trend 0.12). CONCLUSIONS: Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted. Published by Elsevier Ltd.
Authors: Tobias Kurth; J Michael Gaziano; Klaus Berger; Carlos S Kase; Kathryn M Rexrode; Nancy R Cook; Julie E Buring; JoAnn E Manson Journal: Arch Intern Med Date: 2002 Dec 9-23
Authors: David J A Jenkins; Cyril W C Kendall; Augustine Marchie; Tina L Parker; Philip W Connelly; Wei Qian; James S Haight; Dorothea Faulkner; Edward Vidgen; Karen G Lapsley; Gene A Spiller Journal: Circulation Date: 2002-09-10 Impact factor: 29.690
Authors: Ka He; Eric B Rimm; Anwar Merchant; Bernard A Rosner; Meir J Stampfer; Walter C Willett; Alberto Ascherio Journal: JAMA Date: 2002-12-25 Impact factor: 56.272
Authors: Jennifer C Lovejoy; Marlene M Most; Michael Lefevre; Frank L Greenway; Jennifer C Rood Journal: Am J Clin Nutr Date: 2002-11 Impact factor: 7.045
Authors: R di Giuseppe; M K Fjeld; J Dierkes; D Theoflylaktopoulou; M Arregui; H Boeing; C Weikert Journal: Eur J Clin Nutr Date: 2014-10-08 Impact factor: 4.016
Authors: Dagfinn Aune; NaNa Keum; Edward Giovannucci; Lars T Fadnes; Paolo Boffetta; Darren C Greenwood; Serena Tonstad; Lars J Vatten; Elio Riboli; Teresa Norat Journal: BMC Med Date: 2016-12-05 Impact factor: 8.775