IFNgamma mediates DUOX2 expression via a STAT-independent signaling pathway.

The biological roles of the dual oxidases, DUOX1 and DUOX2, are dependent upon the tissue in which they are expressed. However, the mechanisms that control DUOX expression in these tissues are largely unexplored. Given the known role of DUOX for host defense in the gut and respiratory tract, we characterized potential mechanisms that control DUOX2 expression in response to interferon gamma (IFNgamma) in respiratory tract epithelium. We discovered that IFNgamma-mediated DUOX2 expression was regulated by a STAT-independent, JAK-independent pathway. These data provide insights into a novel IFNgamma signaling pathway with potential importance for regulation of host defense responses.