| Literature DB >> 20381233 |
Ingegerd Hellstrom1, Patrick J Heagerty, Elizabeth M Swisher, Pu Liu, Jade Jaffar, Kathy Agnew, Karl Erik Hellstrom.
Abstract
The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20381233 PMCID： PMC3156592 DOI： 10.1016/j.canlet.2010.03.013
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679