Literature DB >> 20381198

Lack of association of PON polymorphisms with sporadic ALS in an Italian population.

Claudia Ricci1, Stefania Battistini, Lorena Cozzi, Michele Benigni, Paola Origone, Lorenzo Verriello, Christian Lunetta, Cristina Cereda, Pamela Milani, Giuseppe Greco, Maria Cristina Patrosso, Renzo Causarano, Claudia Caponnetto, Fabio Giannini, Massimo Corbo, Silvana Penco.   

Abstract

Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20381198     DOI： 10.1016/j.neurobiolaging.2010.02.010

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  12 in total

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