BACKGROUND: An undiagnosed and therefore inadequately treated bipolarity may be an important cause of drug resistance in depression diagnosed as unipolar. The study aimed to detect clinical and demographic characteristics, with a special interest in bipolarity features which could be risk factors for treatment resistance in unipolar depression. METHOD: One-thousand and fifty-one patients recruited from 150 outpatient psychiatric clinics and fulfilling DSM-IV criteria for major depressive episodes, single or recurrent, were studied. Among them, 569 patients with treatment-resistant depression (TR) were compared with 482 patients with non-treatment-resistant depression (NTR). All patients were assessed using the structured demographic and clinical data interviews, Mood Disorder Questionnaire (MDQ) and Hypomania Checklist (HCL-32). RESULTS: Independent risk factors of treatment resistance were: scoring 6 or higher on MDQ, scoring 14 or higher in HCL-32, age at first onset < or = 20 years, more than three previous depressive episodes, and lack of remission or partial remission after the previous depressive episode. LIMITATION: A retrospective assessment of treatment resistance. CONCLUSIONS: Bipolarity features as assessed by MDQ and HCL-32 were identified as significant factors of treatment resistance. Some other clinical variables connected with treatment resistance may be also be associated with bipolarity features. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND: An undiagnosed and therefore inadequately treated bipolarity may be an important cause of drug resistance in depression diagnosed as unipolar. The study aimed to detect clinical and demographic characteristics, with a special interest in bipolarity features which could be risk factors for treatment resistance in unipolar depression. METHOD: One-thousand and fifty-one patients recruited from 150 outpatientpsychiatric clinics and fulfilling DSM-IV criteria for major depressive episodes, single or recurrent, were studied. Among them, 569 patients with treatment-resistant depression (TR) were compared with 482 patients with non-treatment-resistant depression (NTR). All patients were assessed using the structured demographic and clinical data interviews, Mood Disorder Questionnaire (MDQ) and Hypomania Checklist (HCL-32). RESULTS: Independent risk factors of treatment resistance were: scoring 6 or higher on MDQ, scoring 14 or higher in HCL-32, age at first onset < or = 20 years, more than three previous depressive episodes, and lack of remission or partial remission after the previous depressive episode. LIMITATION: A retrospective assessment of treatment resistance. CONCLUSIONS: Bipolarity features as assessed by MDQ and HCL-32 were identified as significant factors of treatment resistance. Some other clinical variables connected with treatment resistance may be also be associated with bipolarity features. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: Moro Maria Francesca; Lecca Maria Efisia; Ghillani M Alessandra; Alacqua Marianna; Carta Mauro Giovanni Journal: Clin Pract Epidemiol Ment Health Date: 2014-03-07
Authors: Frédérique C W van Krugten; Meriam Kaddouri; Maartje Goorden; Anton J L M van Balkom; Claudi L H Bockting; Frenk P M L Peeters; Leona Hakkaart-van Roijen Journal: PLoS One Date: 2017-02-08 Impact factor: 3.240
Authors: Sakina J Rizvi; Etienne Grima; Mary Tan; Susan Rotzinger; Peter Lin; Roger S Mcintyre; Sidney H Kennedy Journal: Can J Psychiatry Date: 2014-07 Impact factor: 4.356
Authors: Nicolas A Nuñez; Stefano Comai; Eduard Dumitrescu; Maykel F Ghabrash; John Tabaka; Marie Saint-Laurent; Stephen Vida; Theodore Kolivakis; Allan Fielding; Nancy Low; Pablo Cervantes; Linda Booij; Gabriella Gobbi Journal: BMC Psychiatry Date: 2018-03-16 Impact factor: 3.630