OBJECTIVE: To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. STUDY DESIGN: Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. RESULTS: Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score <or= 15th percentile, an intelligence quotient <or= 85, and cerebral palsy, and attended special education. CONCLUSION: Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes. Copyright (c) 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: To assess the relation between patterns of brain injury on neonatal and childhood magnetic resonance imaging (MRI) and long-term neurodevelopmental outcome. STUDY DESIGN: Neonatal (n = 34) and childhood MRIs (n = 77) were analyzed for 80 children with neonatal encephalopathy and for 51 control subjects during childhood. MRIs were graded as normal, mildly abnormal (white matter lesions), or moderately/severely abnormal (watershed injury, lesions in basal ganglia/thalamus or focal infarction). Severity of brain injury was related to different aspects of neurologic outcome: Total impairment score of the Movement Assessment Battery for Children, intelligence quotient score, cerebral palsy, postneonatal epilepsy, and need for special education. Seven children with neonatal encephalopathy required extracorporeal membrane oxygenation treatment. RESULTS: Neonatal and childhood MRI were comparable in 25/33 children (75.8%, P < .001). Children with moderate/severe lesions on neonatal or childhood MRI more often had a total impairment score <or= 15th percentile, an intelligence quotient <or= 85, and cerebral palsy, and attended special education. CONCLUSION: Different patterns of injury seen on neonatal MRI after neonatal encephalopathy can still be recognized on childhood MRI. Children with moderate to severe brain lesions on neonatal or childhood MRI significantly more often have impaired motor and cognitive outcomes. Copyright (c) 2010 Mosby, Inc. All rights reserved.
Authors: Hannah C Glass; Karen J Hong; Elizabeth E Rogers; Rita J Jeremy; Sonia L Bonifacio; Joseph E Sullivan; A James Barkovich; Donna M Ferriero Journal: Pediatr Res Date: 2011-11 Impact factor: 3.756
Authors: Seetha Shankaran; Scott A McDonald; Abbot R Laptook; Susan R Hintz; Patrick D Barnes; Abhik Das; Athina Pappas; Rosemary D Higgins Journal: J Pediatr Date: 2015-09-16 Impact factor: 4.406
Authors: Seetha Shankaran; Patrick D Barnes; Susan R Hintz; Abbott R Laptook; Kristin M Zaterka-Baxter; Scott A McDonald; Richard A Ehrenkranz; Michele C Walsh; Jon E Tyson; Edward F Donovan; Ronald N Goldberg; Rebecca Bara; Abhik Das; Neil N Finer; Pablo J Sanchez; Brenda B Poindexter; Krisa P Van Meurs; Waldemar A Carlo; Barbara J Stoll; Shahnaz Duara; Ronnie Guillet; Rosemary D Higgins Journal: Arch Dis Child Fetal Neonatal Ed Date: 2012-11 Impact factor: 5.747