| Literature DB >> 20380897 |
Yunzhi Zhang1, Hailin Zhang, Xingqi Dong, Junfa Yuan, Huajun Zhang, Xinglou Yang, Peng Zhou, Xingyi Ge, Yan Li, Lin-Fa Wang, Zhengli Shi.
Abstract
An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20380897 DOI： 10.1016/j.meegid.2010.03.015
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342