| Literature DB >> 2038053 |
C A Schiffer1, V J Davisson, D V Santi, R M Stroud.
Abstract
Human thymidylate synthase has been crystallized in the absence of ligands and diffracts beyond 3.0 A. The protein was cloned and expressed in Escherichia coli and then crystallized from ammonium sulfate in the presence of beta-mercaptoethanol at a variety of pH values. The crystals are trigonal in the space-group P3(1)21; the unit cell dimensions are a = b = 96.7 A, c = 84.1 A.Entities:
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Year: 1991 PMID： 2038053 DOI： 10.1016/0022-2836(91)90558-n
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469