| Literature DB >> 20380423 |
Akira Kaneko1, Mariko Tsukada, Miyuki Fukai, Toshihiro Suzuki, Kazuto Nishio, Kazuhiko Miki, Kaoru Kinoshita, Kunio Takahashi, Kiyotaka Koyama.
Abstract
Three novel p-terphenyl compounds, named boletopsins A (1), B (2), and C (3), and four known analogues (4-7) were isolated from fruiting bodies of the mushroom Boletopsis leucomelas. Compounds 1-7 were tested for KDR kinase inhibitory activity, and boletopsin C (3) was found to have an IC(50) value of 70.7 microM. Compound 3 also showed inhibition of proliferation of human umbilical vein endothelial cells, with an IC(50) value of 9.04 microM.Entities:
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Year: 2010 PMID： 20380423 DOI： 10.1021/np100113e
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050