AIM: To identify the brain loci that process human biliary sensation. METHODS: In 6 patients (age range: 42-74 years; 4 men), who underwent percutaneous transhepatic biliary drainage (PTBD), the distal biliary tract was stimulated by repeatedly inflating the balloon of the PTBD catheter so that it reached volumes that produced a definite painless sensation. The functional magnetic resonance imaging (fMRI) of the cortical response to biliary sensation was examined. RESULTS: Biliary balloon stimulation elicited activation of the insular cortex, prefrontal cortex, and somatosensory cortex (P < 0.001). CONCLUSION: Biliary balloon stimulation evoked a cerebral cortical response detectable by fMRI.
AIM: To identify the brain loci that process human biliary sensation. METHODS: In 6 patients (age range: 42-74 years; 4 men), who underwent percutaneous transhepatic biliary drainage (PTBD), the distal biliary tract was stimulated by repeatedly inflating the balloon of the PTBD catheter so that it reached volumes that produced a definite painless sensation. The functional magnetic resonance imaging (fMRI) of the cortical response to biliary sensation was examined. RESULTS: Biliary balloon stimulation elicited activation of the insular cortex, prefrontal cortex, and somatosensory cortex (P < 0.001). CONCLUSION: Biliary balloon stimulation evoked a cerebral cortical response detectable by fMRI.
Authors: Charles N Bernstein; Uta N Frankenstein; Patricia Rawsthorne; Marshall Pitz; Randy Summers; Michael C McIntyre Journal: Am J Gastroenterol Date: 2002-02 Impact factor: 10.864
Authors: Q Aziz; J L Andersson; S Valind; A Sundin; S Hamdy; A K Jones; E R Foster; B Långström; D G Thompson Journal: Gastroenterology Date: 1997-07 Impact factor: 22.682
Authors: Joris Vandenberghe; Patrick Dupont; Lukas Van Oudenhove; Guy Bormans; Koen Demyttenaere; Benjamin Fischler; Brecht Geeraerts; Jozef Janssens; Jan Tack Journal: Gastroenterology Date: 2007-03-24 Impact factor: 22.682