OBJECTIVE: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. METHODS: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, N=10) as controls, and those of simple hyperplasia (SH, N=20), complex hyperplasia without atypia (CH, N=20), atypical hyperplasia (AH, N=20), and endometrial cancer (EC, N=31). RESULTS: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p<0.001). Syndecan-1 expression was significantly greater in CH (p<0.001) or AH (p<0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p<0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). CONCLUSION: Syndecan-1 expression appears to be useful as a predictive indicator in endometrial hyperplasia.
OBJECTIVE: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. METHODS: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, N=10) as controls, and those of simple hyperplasia (SH, N=20), complex hyperplasia without atypia (CH, N=20), atypical hyperplasia (AH, N=20), and endometrial cancer (EC, N=31). RESULTS: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p<0.001). Syndecan-1 expression was significantly greater in CH (p<0.001) or AH (p<0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p<0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). CONCLUSION:Syndecan-1 expression appears to be useful as a predictive indicator in endometrial hyperplasia.
Authors: Tobias Zellweger; Christoph Ninck; Martina Mirlacher; Matthias Annefeld; Andrew G Glass; Thomas C Gasser; Michael J Mihatsch; Edward P Gelmann; Lukas Bubendorf Journal: Prostate Date: 2003-04-01 Impact factor: 4.104
Authors: B S Kendall; B M Ronnett; C Isacson; K R Cho; L Hedrick; M Diener-West; R J Kurman Journal: Am J Surg Pathol Date: 1998-08 Impact factor: 6.394
Authors: Y Ito; H Yoshida; K Nakano; Y Takamura; A Miya; K Kobayashi; T Yokozawa; F Matsuzuka; N Matsuura; K Kuma; A Miyauchi Journal: Histopathology Date: 2003-08 Impact factor: 5.087
Authors: Mattia Barbareschi; Patrick Maisonneuve; Daniela Aldovini; Maria Giulia Cangi; Lorenza Pecciarini; Francesco Angelo Mauri; Silvio Veronese; Orazio Caffo; Antonio Lucenti; Paolo Dalla Palma; Enzo Galligioni; Claudio Doglioni Journal: Cancer Date: 2003-08-01 Impact factor: 6.860