Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.

Literature DB >> 20379349

Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.

Bhaskar C Das¹, Sakkarapalayam M Mahalingam, Lipsa Panda, Bo Wang, Phillp Campbell, Todd Evans.

Abstract

Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N, N'-Dicylohexyl cabodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.

Entities: CellLine Chemical Disease Gene Species

Year: 2010 PMID： 20379349 PMCID： PMC2849109 DOI： 10.1016/j.tetlet.2010.01.003

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

7 in total

Review 1. From bench to clinic with apoptosis-based therapeutic agents.

Authors: D W Nicholson
Journal: Nature Date: 2000-10-12 Impact factor: 49.962

Review 2. Apoptosis-based therapies.

Authors: John C Reed
Journal: Nat Rev Drug Discov Date: 2002-02 Impact factor: 84.694

Review 3. Retinoic acid biosynthesis and metabolism.

Authors: J L Napoli
Journal: FASEB J Date: 1996-07 Impact factor: 5.191

Review 4. Apoptosis in the pathogenesis and treatment of disease.

Authors: C B Thompson
Journal: Science Date: 1995-03-10 Impact factor: 47.728

5. Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

Authors: Pelayo Camps; Xavier Formosa; Carles Galdeano; Tània Gómez; Diego Muñoz-Torrero; Michele Scarpellini; Elisabet Viayna; Albert Badia; M Victòria Clos; Antoni Camins; Mercè Pallàs; Manuela Bartolini; Francesca Mancini; Vincenza Andrisano; Joan Estelrich; Mònica Lizondo; Axel Bidon-Chanal; F Javier Luque
Journal: J Med Chem Date: 2008-06-03 Impact factor: 7.446

6. Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol.

Authors: Bhaskar C Das; Sakkarapalayam M Mahalingam; Todd Evans; George W Kabalka; J Anguiano; K Hema
Journal: Chem Commun (Camb) Date: 2009-03-09 Impact factor: 6.222

Review 7. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

Authors: J F Kerr; A H Wyllie; A R Currie
Journal: Br J Cancer Date: 1972-08 Impact factor: 7.640

7 in total

1. Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors.

Authors: Bhaskar C Das; Xiaoping Zhao; Xiang-Ying Tang; Fajun Yang
Journal: Bioorg Med Chem Lett Date: 2011-06-28 Impact factor: 2.823

2. Biosynthesis of (R)-(+)-perillyl alcohol by Escherichia coli expressing neryl pyrophosphate synthase.

Authors: Chao Sun; Rubing Zhang; Congxia Xie
Journal: Eng Life Sci Date: 2022-02-13 Impact factor: 3.405

3. Efficient Synthesis of (R)-(+)-Perillyl Alcohol From (R)-(+)-Limonene Using Engineered Escherichia coli Whole Cell Biocatalyst.

Authors: Chao Sun; Rubing Zhang; Congxia Xie
Journal: Front Bioeng Biotechnol Date: 2022-04-25

Review 7. Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs.

Authors: Yusif M Mukhtar; Michael Adu-Frimpong; Ximing Xu; Jiangnan Yu
Journal: Biosci Rep Date: 2018-11-13 Impact factor: 3.840

7 in total

Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.

Review 1. From bench to clinic with apoptosis-based therapeutic agents.

Review 2. Apoptosis-based therapies.

Review 3. Retinoic acid biosynthesis and metabolism.

Review 4. Apoptosis in the pathogenesis and treatment of disease.

5. Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.

6. Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol.

Review 7. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

1. Design, synthesis and biological study of pinacolyl boronate-substituted stilbenes as novel lipogenic inhibitors.

2. Biosynthesis of (R)-(+)-perillyl alcohol by Escherichia coli expressing neryl pyrophosphate synthase.

3. Efficient Synthesis of (R)-(+)-Perillyl Alcohol From (R)-(+)-Limonene Using Engineered Escherichia coli Whole Cell Biocatalyst.

4. The identification of perillyl alcohol glycosides with improved antiproliferative activity.

5. Small molecules targeting LapB protein prevent Listeria attachment to catfish muscle.

6. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.

Review 7. Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs.