AIMS: Although the clinical implications of prolonged Q-T interval have been described, the clinical determinants of Q-T interval in type 2 diabetes mellitus are not clear. We examined the influencing factors of QTc in type 2 diabetes mellitus. METHODS: This study involved 207 patients with type 2 diabetes mellitus and 141 healthy controls. QTc was estimated from resting lead II electrocardiogram. Data analysis was done using unpaired Student's 't' and Pearson correlation tests. RESULTS: Only female diabetics with somatic neuropathy had longer QTc compared to controls (p<0.01). Only in male diabetics negative correlation was found between QTc and heart rate response to deep breathing (p<0.01). Male and female study subjects with diabetic retinopathy had longer QTc compared to controls (p<0.01, 0.05). Only male diabetics with hypertension had longer QTc compared to controls (p<0.05). CONCLUSION: QTc prolongation is associated with diabetic neuropathy with sex difference in its manifestation. It is influenced by diabetic retinopathy in male and female diabetics. It is influenced by hypertension in male type 2 diabetics. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
AIMS: Although the clinical implications of prolonged Q-T interval have been described, the clinical determinants of Q-T interval in type 2 diabetes mellitus are not clear. We examined the influencing factors of QTc in type 2 diabetes mellitus. METHODS: This study involved 207 patients with type 2 diabetes mellitus and 141 healthy controls. QTc was estimated from resting lead II electrocardiogram. Data analysis was done using unpaired Student's 't' and Pearson correlation tests. RESULTS: Only female diabetics with somatic neuropathy had longer QTc compared to controls (p<0.01). Only in male diabetics negative correlation was found between QTc and heart rate response to deep breathing (p<0.01). Male and female study subjects with diabetic retinopathy had longer QTc compared to controls (p<0.01, 0.05). Only male diabetics with hypertension had longer QTc compared to controls (p<0.05). CONCLUSION:QTc prolongation is associated with diabetic neuropathy with sex difference in its manifestation. It is influenced by diabetic retinopathy in male and female diabetics. It is influenced by hypertension in male type 2 diabetics. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Vladan M Ninkovic; Srdjan M Ninkovic; Vanja Miloradovic; Dejan Stanojevic; Marijana Babic; Vojislav Giga; Milan Dobric; Michael I Trenell; Nebojsa Lalic; Petar M Seferovic; Djordje G Jakovljevic Journal: Acta Diabetol Date: 2016-04-23 Impact factor: 4.280
Authors: Kathleen Bird; Gabriel Chan; Huiqi Lu; Heloise Greeff; John Allen; Derek Abbott; Carlo Menon; Nigel H Lovell; Newton Howard; Wee-Shian Chan; Richard Ribon Fletcher; Aymen Alian; Rabab Ward; Mohamed Elgendi Journal: Front Med (Lausanne) Date: 2020-12-04