BACKGROUND: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. METHODS: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infant PCB concentrations and the antibody concentrations evaluated at 6-months of age. RESULTS: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. CONCLUSIONS: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age. Published by Elsevier Inc.
BACKGROUND: Extensive experimental data in animals indicate that exposure to polychlorinated biphenyls (PCBs) during pregnancy leads to changes in offspring immune function during the postnatal period. Whether developmental PCB exposure influences immunologic development in humans has received little study. METHODS: The study population was 384 mother-infant pairs recruited from two districts of eastern Slovakia for whom prospectively collected maternal, cord, and 6-month infant blood specimens were available. Several PCB congeners were measured in maternal, cord, and 6-month infant sera by high-resolution gas chromatography with electron capture detection. Concentrations of IgG-specific anti-haemophilus influenzae type b, tetanus toxoid, and diphtheria toxoid were assayed in 6-month infant sera using ELISA methods. Multiple linear regression was used to estimate the relation between maternal, cord, and 6-month infantPCB concentrations and the antibody concentrations evaluated at 6-months of age. RESULTS: Overall, there was little evidence of an association between infant antibody concentrations and PCB measures during the pre- and early postnatal period. In addition, our results did not show specificity in terms of associations limited to a particular developmental period (e.g. pre- vs. postnatal), a particular antibody, or a particular PCB congener. CONCLUSIONS: At the PCB concentrations measured in this cohort, which are high relative to most human populations today, we did not detect an association between maternal or early postnatal PCB exposure and specific antibody responses at 6-months of age. Published by Elsevier Inc.
Authors: J H Eysteinsdottir; J Freysdottir; A Haraldsson; J Stefansdottir; I Skaftadottir; H Helgason; H M Ogmundsdottir Journal: Clin Exp Immunol Date: 2004-05 Impact factor: 4.330
Authors: Rebecca A James; Irva Hertz-Picciotto; Eric Willman; Jean A Keller; M Judith Charles Journal: Environ Health Perspect Date: 2002-07 Impact factor: 9.031
Authors: Hye-Youn Park; Irva Hertz-Picciotto; Jan Petrik; Lubica Palkovicova; Anton Kocan; Tomas Trnovec Journal: Environ Health Perspect Date: 2008-01 Impact factor: 9.031
Authors: Sisir K Dutta; Partha S Mitra; Somiranjan Ghosh; Shizhu Zang; Dean Sonneborn; Irva Hertz-Picciotto; Tomas Trnovec; Lubica Palkovicova; Eva Sovcikova; Svetlana Ghimbovschi; Eric P Hoffman Journal: Environ Int Date: 2011-09-08 Impact factor: 9.621
Authors: Todd A Jusko; Anneclaire J De Roos; Stephen M Schwartz; B Paige Lawrence; Lubica Palkovicova; Tomas Nemessanyi; Beata Drobna; Anna Fabisikova; Anton Kocan; Eva Jahnova; Terrance J Kavanagh; Tomas Trnovec; Irva Hertz-Picciotto Journal: J Immunotoxicol Date: 2011 Jan-Mar Impact factor: 3.000
Authors: Kinga Lancz; Irva Hertz-Picciotto; Todd A Jusko; Lubica Murínová; Soňa Wimmerová; Eva Sovčíková; Ladislav Dedík; Maximilián Strémy; Beata Drobná; Dana Farkašová; Tomáš Trnovec Journal: Environ Res Date: 2014-11-20 Impact factor: 6.498
Authors: Regina M Simeone; Penelope P Howards; Elizabeth Anderson; Todd A Jusko; Beata Drobná; Anton Kočan; Kamil Čonka; Anna Fabišiková; Ľubica Palkovičová Murínová; Richard L Canfield; Dean Sonneborn; Soňa Wimmerová; Kelly Thevenet-Morrison; Tomáš Trnovec; Irva Hertz-Picciotto; Eva Šovčíková Journal: Chemosphere Date: 2021-09-28 Impact factor: 8.943
Authors: Soňa Wimmerová; Alan Watson; Beata Drobná; Eva Šovčíková; Roland Weber; Kinga Lancz; Henrieta Patayová; Denisa Richterová; Vladimíra Koštiaková; Dana Jurečková; Pavol Závacký; Maximilián Strémy; Todd A Jusko; Ľubica Palkovičová Murínová; Irva Hertz-Picciotto; Tomáš Trnovec Journal: Environ Sci Pollut Res Int Date: 2015-08-07 Impact factor: 4.223
Authors: Todd A Jusko; Dean Sonneborn; Lubica Palkovicova; Anton Kocan; Beata Drobna; Tomas Trnovec; Irva Hertz-Picciotto Journal: Environ Health Perspect Date: 2012-01-03 Impact factor: 9.031