Literature DB >> 20377254

Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems.

Masayasu Taki1, Shohei Iyoshi, Akio Ojida, Itaru Hamachi, Yukio Yamamoto.   

Abstract

We describe here the new copper-selective fluorescent probes FluTPA1 and FluTPA2, in which the tetradentate ligand tris[(2-pyridyl)methyl]amine (TPA) is connected to a reduced form of a fluorescein platform through a benzyl ether linkage. These probes selectively react with copper ions in the presence of submillimolar glutathione and emit intense green fluorescence from the reaction product, O-methylfluorescein. Confocal images of live cells further show that FluTPA2 is membrane-permeable and allows visualization of Cu(I) present in living cells.

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Year:  2010        PMID： 20377254     DOI： 10.1021/ja100714p

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  32 in total

1.  Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model.

Authors:  Tasuku Hirayama; Genevieve C Van de Bittner; Lawrence W Gray; Svetlana Lutsenko; Christopher J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

2.  A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model.

Authors:  Emily L Que; Elizabeth J New; Christopher J Chang
Journal:  Chem Sci       Date:  2012-04-18       Impact factor: 9.825

Review 3.  The molecular basis of memory. Part 2: chemistry of the tripartite mechanism.

Authors:  Gerard Marx; Chaim Gilon
Journal:  ACS Chem Neurosci       Date:  2013-03-21       Impact factor: 4.418

4.  High-contrast Cu(I)-selective fluorescent probes based on synergistic electronic and conformational switching.

Authors:  Aneese F Chaudhry; Subrata Mandal; Kenneth I Hardcastle; Christoph J Fahrni
Journal:  Chem Sci       Date:  2011       Impact factor: 9.825

5.  A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis.

Authors:  Sheel C Dodani; Scot C Leary; Paul A Cobine; Dennis R Winge; Christopher J Chang
Journal:  J Am Chem Soc       Date:  2011-05-12       Impact factor: 15.419

Review 6.  Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling.

Authors:  Cheri M Ackerman; Sumin Lee; Christopher J Chang
Journal:  Anal Chem       Date:  2016-12-15       Impact factor: 6.986

Review 7.  Activity-based sensing fluorescent probes for iron in biological systems.

Authors:  Allegra T Aron; Audrey G Reeves; Christopher J Chang
Journal:  Curr Opin Chem Biol       Date:  2018-01-05       Impact factor: 8.822

Review 8.  Opportunities in multidimensional trace metal imaging: taking copper-associated disease research to the next level.

Authors:  Stefan Vogt; Martina Ralle
Journal:  Anal Bioanal Chem       Date:  2012-10-19       Impact factor: 4.142

9.  A Readily-Synthesized Fluorescent Probe Based on N, N-Bis (Pyridin-2-Ylmethyl) Aniline for Copper(II) Detection in Aqueous Solution.

Authors:  Xiaoyu Liu; Yuan Zhang
Journal:  J Fluoresc       Date:  2016-09-06       Impact factor: 2.217

10.  Photoactivatable fluorescein derivatives caged with a (3-hydroxy-2-naphthalenyl)methyl group.

Authors:  Emmanuel E Nekongo; Vladimir V Popik
Journal:  J Org Chem       Date:  2014-08-01       Impact factor: 4.354
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