Literature DB >> 20376509

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans.

Elena M Cornejo Castro1, Jens Waak, Stephanie S Weber, Fabienne C Fiesel, Philipp Oberhettinger, Monika Schütz, Ingo B Autenrieth, Wolfdieter Springer, Philipp J Kahle.   

Abstract

DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.

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Year:  2010        PMID： 20376509     DOI： 10.1007/s00702-010-0397-4

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  25 in total

1.  The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.

Authors:  Rosa M Canet-Avilés; Mark A Wilson; David W Miller; Rili Ahmad; Chris McLendon; Sourav Bandyopadhyay; Melisa J Baptista; Dagmar Ringe; Gregory A Petsko; Mark R Cookson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-04       Impact factor: 11.205

2.  Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.

Authors:  Eunsung Junn; Hiroyuki Taniguchi; Byeong Seon Jeong; Xin Zhao; Hidenori Ichijo; M Maral Mouradian
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-27       Impact factor: 11.205

3.  The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.

Authors:  Jin Xu; Nan Zhong; Haoyong Wang; Joshua E Elias; Christina Y Kim; Irina Woldman; Christian Pifl; Steven P Gygi; Changiz Geula; Bruce A Yankner
Journal:  Hum Mol Genet       Date:  2005-03-24       Impact factor: 6.150

4.  The CUB domain. A widespread module in developmentally regulated proteins.

Authors:  P Bork; G Beckmann
Journal:  J Mol Biol       Date:  1993-05-20       Impact factor: 5.469

5.  Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1.

Authors:  Karin Görner; Eve Holtorf; Jens Waak; Thu-Trang Pham; Daniela M Vogt-Weisenhorn; Wolfgang Wurst; Christian Haass; Philipp J Kahle
Journal:  J Biol Chem       Date:  2007-03-01       Impact factor: 5.157

6.  Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.

Authors:  Jens Waak; Stephanie S Weber; Karin Görner; Christoph Schall; Hidenori Ichijo; Thilo Stehle; Philipp J Kahle
Journal:  J Biol Chem       Date:  2009-03-16       Impact factor: 5.157

Review 7.  Divergent roles for C-type lectins expressed by cells of the innate immune system.

Authors:  Eamon P McGreal; Luisa Martinez-Pomares; Siamon Gordon
Journal:  Mol Immunol       Date:  2004-11       Impact factor: 4.407

8.  Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.

Authors:  Vincenzo Bonifati; Patrizia Rizzu; Marijke J van Baren; Onno Schaap; Guido J Breedveld; Elmar Krieger; Marieke C J Dekker; Ferdinando Squitieri; Pablo Ibanez; Marijke Joosse; Jeroen W van Dongen; Nicola Vanacore; John C van Swieten; Alexis Brice; Giuseppe Meco; Cornelia M van Duijn; Ben A Oostra; Peter Heutink
Journal:  Science       Date:  2002-11-21       Impact factor: 47.728

9.  The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.

Authors:  Rina Bandopadhyay; Ann E Kingsbury; Mark R Cookson; Andrew R Reid; Ian M Evans; Andrew D Hope; Alan M Pittman; Tammaryn Lashley; Rosa Canet-Aviles; David W Miller; Chris McLendon; Catherine Strand; Andrew J Leonard; Patrick M Abou-Sleiman; Daniel G Healy; Hiroyashi Ariga; Nicholas W Wood; Rohan de Silva; Tamas Revesz; John A Hardy; Andrew J Lees
Journal:  Brain       Date:  2003-12-08       Impact factor: 13.501

10.  p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

Authors:  Emily R Troemel; Stephanie W Chu; Valerie Reinke; Siu Sylvia Lee; Frederick M Ausubel; Dennis H Kim
Journal:  PLoS Genet       Date:  2006-09-11       Impact factor: 5.917
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  14 in total

Review 1.  Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.

Authors:  Márcio S Baptista; Carlos B Duarte; Patrícia Maciel
Journal:  Cell Mol Life Sci       Date:  2012-03-03       Impact factor: 9.261

2.  Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity.

Authors:  Julianne Martell; Yonghak Seo; Daniel W Bak; Samuel F Kingsley; Heidi A Tissenbaum; Eranthie Weerapana
Journal:  Cell Chem Biol       Date:  2016-08-04       Impact factor: 8.116

3.  A Caenorhabditis elegans p38 MAP kinase pathway mutant protects from dopamine, methamphetamine, and MDMA toxicity.

Authors:  Matthew A Schreiber; Steven L McIntire
Journal:  Neurosci Lett       Date:  2011-05-05       Impact factor: 3.046

4.  Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans.

Authors:  Andreas Hanno Ludewig; Maja Klapper; Frank Döring
Journal:  Genes Nutr       Date:  2013-12-06       Impact factor: 5.523

5.  Apoptosis signal regulating kinase 1 deletion mitigates α-synuclein pre-formed fibril propagation in mice.

Authors:  Jie Zhang; Eun S Park; Hye-Jin Park; Run Yan; Magda Grudniewska; Xiaopei Zhang; Stephanie Oh; Xue Yang; Jean Baum; M Maral Mouradian
Journal:  Neurobiol Aging       Date:  2019-09-25       Impact factor: 4.673

6.  The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2.

Authors:  Queenie Hu; Dayana R D'Amora; Lesley T MacNeil; Albertha J M Walhout; Terrance J Kubiseski
Journal:  Genetics       Date:  2017-06-09       Impact factor: 4.562

7.  Aspects of innate immunity and Parkinson's disease.

Authors:  Yue Huang; Glenda M Halliday
Journal:  Front Pharmacol       Date:  2012-03-08       Impact factor: 5.810

8.  C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.

Authors:  Ebany J Martinez-Finley; Sudipta Chakraborty; Sam Caito; Stephanie Fretham; Michael Aschner
Journal:  Adv Med Biol       Date:  2012

9.  n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.

Authors:  Ru-Huei Fu; Horng-Jyh Harn; Shih-Ping Liu; Chang-Shi Chen; Wen-Lin Chang; Yue-Mi Chen; Jing-En Huang; Rong-Jhu Li; Sung-Yu Tsai; Huey-Shan Hung; Woei-Cherng Shyu; Shinn-Zong Lin; Yu-Chi Wang
Journal:  PLoS One       Date:  2014-01-08       Impact factor: 3.240

10.  Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans.

Authors:  Muntasir Kamal; Dayana R D'Amora; Terrance J Kubiseski
Journal:  BMC Cell Biol       Date:  2016-09-13       Impact factor: 4.241
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