Esophagus: How should early neoplasia in Barrett esophagus be treated?

The appropriate management of patients with Barrett esophagus in whom early carcinoma or high-grade intraepithelial neoplasia has been detected continues to be a subject of controversy. For many years radical esophageal resection has been regarded as the treatment of choice, but the high morbidity and mortality rates associated with this procedure have led to less radical treatment strategies being advocated by many groups.