Literature DB >> 20376093

Hepatitis: Treatment of chronic hepatitis C-how much interferon is enough?

Peter Ferenci1.   

Abstract

A multicenter, randomized, controlled trial of 610 patients with chronic hepatitis c infected with hcv genotype 1 or 4 compared 48 weeks of standard of care therapy (PEG-IFN and ribavirin) with 12 weeks of induction therapy with high-dose PEG-IFN followed by 36 weeks of standard of care treatment. High-dose PEG-IFN induction therapy did not enhance early or sustained virologic response rates compared with standard of care therapy.

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Year:  2010        PMID: 20376093     DOI: 10.1038/nrgastro.2010.40

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN: 1759-5045            Impact factor:   46.802


  10 in total

Review 1.  Induction therapy in chronic hepatitis C: déjà-vu with pegylated interferons?

Authors:  Stefan Zeuzem
Journal:  J Hepatol       Date:  2004-09       Impact factor: 25.083

2.  Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

Authors:  A U Neumann; N P Lam; H Dahari; D R Gretch; T E Wiley; T J Layden; A S Perelson
Journal:  Science       Date:  1998-10-02       Impact factor: 47.728

3.  Viral kinetics in genotype 1 chronic hepatitis C patients during therapy with 2 different doses of peginterferon alfa-2b plus ribavirin.

Authors:  Maria Buti; Francisco Sanchez-Avila; Yoav Lurie; Carlos Stalgis; Auristela Valdés; Maria Martell; Rafael Esteban
Journal:  Hepatology       Date:  2002-04       Impact factor: 17.425

Review 4.  Hepatitis C virus infection and apoptosis.

Authors:  Richard Fischer; Thomas Baumert; Hubert-E Blum
Journal:  World J Gastroenterol       Date:  2007-09-28       Impact factor: 5.742

5.  Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha2b: a randomized trial.

Authors:  Donald M Jensen; Patrick Marcellin; Bradley Freilich; Pietro Andreone; Adrian Di Bisceglie; Carlos E Brandão-Mello; K Rajender Reddy; Antonio Craxi; Antonio Olveira Martin; Gerlinde Teuber; Diethelm Messinger; James A Thommes; Andreas Tietz
Journal:  Ann Intern Med       Date:  2009-04-21       Impact factor: 25.391

Review 6.  Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.

Authors:  Stacy M Horner; Michael Gale
Journal:  J Interferon Cytokine Res       Date:  2009-09       Impact factor: 2.607

Review 7.  Optimizing outcomes in patients with hepatitis C virus genotype 1 or 4.

Authors:  Samuel S Lee; Peter Ferenci
Journal:  Antivir Ther       Date:  2008

8.  Impact of high-dose peginterferon alfa-2A on virological response rates in patients with hepatitis C genotype 1: a randomized controlled trial.

Authors:  Stuart K Roberts; Martin D Weltman; Darrell H G Crawford; Geoffrey W McCaughan; William Sievert; Wendy S Cheng; William Rawlinson; Paul V Desmond; Phillipa S Marks; Motoko Yoshihara; Bishoy Rizkalla; Jean K Depamphilis; Gregory J Dore
Journal:  Hepatology       Date:  2009-10       Impact factor: 17.425

9.  Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

Authors:  Dongliang Ge; Jacques Fellay; Alexander J Thompson; Jason S Simon; Kevin V Shianna; Thomas J Urban; Erin L Heinzen; Ping Qiu; Arthur H Bertelsen; Andrew J Muir; Mark Sulkowski; John G McHutchison; David B Goldstein
Journal:  Nature       Date:  2009-08-16       Impact factor: 49.962

10.  Induction pegylated interferon alfa-2b in combination with ribavirin in patients with genotypes 1 and 4 chronic hepatitis C: a prospective, randomized, multicenter, open-label study.

Authors:  Daniel E Brady; Dawn M Torres; Jong W An; John A Ward; Eric Lawitz; Stephen A Harrison
Journal:  Clin Gastroenterol Hepatol       Date:  2009-09-10       Impact factor: 11.382

  10 in total

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