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Literature DB >> 20376007

Mechanism matters.

Abstract

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Year: 2010 PMID： 20376007 DOI： 10.1038/nm0410-347

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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4 in total

1. Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer.

Authors: S Bachurin; E Bukatina; N Lermontova; S Tkachenko; A Afanasiev; V Grigoriev; I Grigorieva; Y Ivanov; S Sablin; N Zefirov
Journal: Ann N Y Acad Sci Date: 2001-06 Impact factor: 5.691

2. Mitochondria as a target for neurotoxins and neuroprotective agents.

Authors: Sergey O Bachurin; Elena P Shevtsova; Elena G Kireeva; Gregory F Oxenkrug; Sergey O Sablin
Journal: Ann N Y Acad Sci Date: 2003-05 Impact factor: 5.691

3. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study.

Authors: Rachelle S Doody; Svetlana I Gavrilova; Mary Sano; Ronald G Thomas; Paul S Aisen; Sergey O Bachurin; Lynn Seely; David Hung
Journal: Lancet Date: 2008-07-19 Impact factor: 79.321

4. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo.

Authors: John W Steele; Soong H Kim; John R Cirrito; Deborah K Verges; Jessica L Restivo; David Westaway; Paul Fraser; Peter St George Hyslop; Mary Sano; Ilya Bezprozvanny; Michelle E Ehrlich; David M Holtzman; Sam Gandy
Journal: Mol Neurodegener Date: 2009-12-17 Impact factor: 14.195

4 in total

22 in total

Review 1. Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models.

Authors: Megan M Yardley; Lara A Ray
Journal: Addict Biol Date: 2016-02-01 Impact factor: 4.280

2. Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology.

Authors: Jan M Keppel Hesselink
Journal: J Neurol Date: 2017-03-27 Impact factor: 4.849

3. A multichannel nanosensor for instantaneous readout of cancer drug mechanisms.

Authors: Subinoy Rana; Ngoc D B Le; Rubul Mout; Krishnendu Saha; Gulen Yesilbag Tonga; Robert E S Bain; Oscar R Miranda; Caren M Rotello; Vincent M Rotello
Journal: Nat Nanotechnol Date: 2014-12-15 Impact factor: 39.213

Review 4. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I).

Authors: Marius Mioc; Andreea Milan; Daniel Malița; Alexandra Mioc; Alexandra Prodea; Roxana Racoviceanu; Roxana Ghiulai; Andreea Cristea; Florina Căruntu; Codruța Șoica
Journal: Int J Mol Sci Date: 2022-07-13 Impact factor: 6.208

5. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

Authors: Prashant R Bharadwaj; Giuseppe Verdile; Renae K Barr; Veer Gupta; John W Steele; M Lenard Lachenmayer; Zhenyu Yue; Michelle E Ehrlich; Gregory Petsko; Shulin Ju; Dagmar Ringe; Sonia E Sankovich; Joanne M Caine; Ian G Macreadie; Sam Gandy; Ralph N Martins
Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472

Mechanism matters.

1. Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer.

2. Mitochondria as a target for neurotoxins and neuroprotective agents.

3. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study.

4. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo.

Review 1. Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models.

2. Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology.

3. A multichannel nanosensor for instantaneous readout of cancer drug mechanisms.

Review 4. Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I).

5. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

6. Combination of Miconazole and Domiphen Bromide Is Fungicidal against Biofilms of Resistant Candida spp.

7. Predicting mechanism of action of novel compounds using compound structure and transcriptomic signature coembedding.

Review 8. Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.

9. Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors.

Review 10. Elucidating the Mechanisms of Action of Antimicrobial Agents.