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Literature DB >> 20375570

Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.

M D Carlisle¹, R N Srikantha, K A Brogden.

Abstract

Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions. Copyright 2008 S. Karger AG, Basel.

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Year: 2008 PMID： 20375570 PMCID： PMC7312840 DOI： 10.1159/000181015

Source DB: PubMed Journal: J Innate Immun ISSN： 1662-811X Impact factor: 7.349

35 in total

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