Literature DB >> 20375001

Finding new cures for neurological disorders: a possible fringe benefit of biodefense research?

David A Jett1.   

Abstract

The National Institutes of Health (NIH) supports research about and the development of better therapies for treating exposure to toxic chemicals that could be used in a terrorist attack or released during an industrial accident. A review of recent research published by NIH investigators working in this field indicates that scientific advances in this area also have implications for reducing the burden of other neurological diseases and disorders. Some key examples discussed include studies on the development of therapeutic drugs to treat seizures and the neuropathology caused by chemical nerve agents, which may help find better cures for epilepsy, stroke, and neurodegenerative diseases.

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Year:  2010        PMID： 20375001     DOI： 10.1126/scitranslmed.3000752

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  12 in total

1.  Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

Authors:  Marson Putra; Shaunik Sharma; Meghan Gage; Grace Gasser; Andy Hinojo-Perez; Ashley Olson; Adriana Gregory-Flores; Sreekanth Puttachary; Chong Wang; Vellareddy Anantharam; Thimmasettappa Thippeswamy
Journal:  Neurobiol Dis       Date:  2019-03-30       Impact factor: 5.996

2.  Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus.

Authors:  Jennifer N Pearson; Kalynn M Schulz; Manisha Patel
Journal:  Epilepsy Res       Date:  2014-04-29       Impact factor: 3.045

3.  Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model.

Authors:  Li-Ping Liang; Jennifer N Pearson-Smith; Jie Huang; Pallavi McElroy; Brian J Day; Manisha Patel
Journal:  Toxicol Sci       Date:  2018-04-01       Impact factor: 4.849

Review 4.  Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication.

Authors:  Laxmikant S Deshpande; Robert E Blair; Kristin F Phillips; Robert J DeLorenzo
Journal:  Ann N Y Acad Sci       Date:  2016-06-21       Impact factor: 5.691

5.  Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy.

Authors:  Jennifer N Pearson; Shane Rowley; Li-Ping Liang; Andrew M White; Brian J Day; Manisha Patel
Journal:  Neurobiol Dis       Date:  2015-07-13       Impact factor: 5.996

6.  Oxidative Stress Contributes to Status Epilepticus Associated Mortality.

Authors:  Jennifer N Pearson-Smith; Li-Ping Liang; Shane D Rowley; Brian J Day; Manisha Patel
Journal:  Neurochem Res       Date:  2017-05-02       Impact factor: 3.996

7.  Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus.

Authors:  Laxmikant S Deshpande; Robert E Blair; Matthew Halquist; Leon Kosmider; Robert J DeLorenzo
Journal:  Ann N Y Acad Sci       Date:  2020-09-22       Impact factor: 5.691

Review 8.  The role of oxidative stress in organophosphate and nerve agent toxicity.

Authors:  Jennifer N Pearson; Manisha Patel
Journal:  Ann N Y Acad Sci       Date:  2016-07-02       Impact factor: 5.691

9.  Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.

Authors:  Randall T Peterson; Calum A Macrae
Journal:  Drug Discov Today Dis Models       Date:  2013

10.  Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Authors:  Andrew C Hemmert; Tamara C Otto; Roberto A Chica; Monika Wierdl; Jonathan S Edwards; Steven M Lewis; Steven L Lewis; Carol C Edwards; Lyudmila Tsurkan; C Linn Cadieux; Shane A Kasten; John R Cashman; Stephen L Mayo; Philip M Potter; Douglas M Cerasoli; Matthew R Redinbo
Journal:  PLoS One       Date:  2011-03-18       Impact factor: 3.240
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