B Yan1, Y Li, J Pan, H Xia, L-J Li. 1. State Key Laboratory of Oral Disease, Sichuan University, Chengdu, China.
Abstract
PURPOSE: As a review and clinical analysis of primary oral leiomyosarcoma (LMS) cases in West China stomatology Hospital in the past 37 years, this study provides demographic, therapeutic and prognostic information of this rare tumor. PATIENTS AND METHODS: In our study, 20 cases of primary oral LMS treated between 1972 and 2008 in West China Stomatology Hospital were analyzed retrospectively. A thorough review of clinical records was carried out and potential indicators of survival were analyzed. RESULTS: The most common symptom of oral LMS presented as a painless mass. The median age of patients was 37 years, and the peak incidence age of this tumor was in the 2nd and 5th decades. There was no predilection of gender, and the male-to-female ratio was 11:9. The most frequently occurring site of oral leiomysarcoma was the jawbones. The prognosis of this tumor was poor as a result of the high local recurrence and the estimated 2 year survival was 17.6%. The bony involvement and method of therapy was observed to have an influence on the prognosis and survival of this tumor (P < 0.05). CONCLUSION: There was a predilection site of jawbones for oral LMS, and bony involvement was a potential indicator suggesting a poorer prognosis. The recommended method of therapy on this tumor was aggressive, radical surgical resection; however, adjuvant radiotherapy and chemotherapy may also have a beneficial effect.
PURPOSE: As a review and clinical analysis of primary oral leiomyosarcoma (LMS) cases in West China stomatology Hospital in the past 37 years, this study provides demographic, therapeutic and prognostic information of this rare tumor. PATIENTS AND METHODS: In our study, 20 cases of primary oral LMS treated between 1972 and 2008 in West China Stomatology Hospital were analyzed retrospectively. A thorough review of clinical records was carried out and potential indicators of survival were analyzed. RESULTS: The most common symptom of oral LMS presented as a painless mass. The median age of patients was 37 years, and the peak incidence age of this tumor was in the 2nd and 5th decades. There was no predilection of gender, and the male-to-female ratio was 11:9. The most frequently occurring site of oral leiomysarcoma was the jawbones. The prognosis of this tumor was poor as a result of the high local recurrence and the estimated 2 year survival was 17.6%. The bony involvement and method of therapy was observed to have an influence on the prognosis and survival of this tumor (P < 0.05). CONCLUSION: There was a predilection site of jawbones for oral LMS, and bony involvement was a potential indicator suggesting a poorer prognosis. The recommended method of therapy on this tumor was aggressive, radical surgical resection; however, adjuvant radiotherapy and chemotherapy may also have a beneficial effect.
Authors: Gabriela Ribeiro de Araújo; Sara Ferreira Dos Santos Costa; Ricardo Alves Mesquita; Ricardo Santiago Gomez; Jean Nunes Dos Santos; Hélder Antônio Rebelo Pontes; Bruno Augusto Benevenuto de Andrade; Mário José Romañach; Michelle Agostini; Pablo Agustin Vargas; Cinthia Verônica Bardalez Lopez de Cáceres; Alan Roger Santos-Silva; Ana Carolina Prado Ribeiro; Thaís Bianca Brandão; Ramiro Alejandro Tomasi; Ruth Salomé Ferreyra; Oslei Paes de Almeida; Felipe Paiva Fonseca Journal: Head Neck Pathol Date: 2021-06-09