OBJECTIVES: To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women. DESIGN: Prospective study of mortality. SETTING: A cohort study of health and aging. PARTICIPANTS: Three thousand twenty-seven community-dwelling women from the Study of Osteoporotic Fractures cohort (mean age 84). MEASUREMENTS: Activity data were collected using wrist actigraphy for a minimum of three 24-hour periods, and circadian activity rhythms were computed. Parameters of interest included height of activity peak (amplitude), midline estimating statistic of rhythm (mesor), strength of activity rhythm (robustness), and time of peak activity (acrophase). Vital status, with cause of death adjudicated through death certificates, was prospectively ascertained. RESULTS: Over an average of 4.1 years of follow-up, there were 444 (14.7%) deaths. There was an inverse association between peak activity height and all-cause mortality rates, with higher mortality rates observed in the lowest activity quartile (hazard ratio (HR)=2.18, 95% confidence interval (CI)=1.63-2.92) than in the highest quartile after adjusting for age, clinic site, race, body mass index, cognitive function, exercise, instrumental activity of daily living impairments, depression, medications, alcohol, smoking, self-reported health status, married status, and comorbidities. A greater risk of mortality from all causes was observed for those in the lowest quartiles of mesor (HR=1.71, 95% CI=1.29-2.27) and rhythm robustness (HR=1.97, 95% CI=1.50-2.60) than for those in the highest quartiles. Greater mortality from cancer (HR=2.09, 95% CI=1.04-4.22) and stroke (HR=2.64, 95% CI=1.11-6.30) was observed for later peak activity (after 4:33 p.m.; >1.5 SD from mean) than for the mean peak range (2:50-4:33 p.m.). CONCLUSION: Older women with weak circadian activity rhythms have higher mortality risk. If confirmed in other cohorts, studies will be needed to test whether interventions (e.g., physical activity, bright light exposure) that regulate circadian activity rhythms will improve health outcomes in older adults.
OBJECTIVES: To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women. DESIGN: Prospective study of mortality. SETTING: A cohort study of health and aging. PARTICIPANTS: Three thousand twenty-seven community-dwelling women from the Study of Osteoporotic Fractures cohort (mean age 84). MEASUREMENTS: Activity data were collected using wrist actigraphy for a minimum of three 24-hour periods, and circadian activity rhythms were computed. Parameters of interest included height of activity peak (amplitude), midline estimating statistic of rhythm (mesor), strength of activity rhythm (robustness), and time of peak activity (acrophase). Vital status, with cause of death adjudicated through death certificates, was prospectively ascertained. RESULTS: Over an average of 4.1 years of follow-up, there were 444 (14.7%) deaths. There was an inverse association between peak activity height and all-cause mortality rates, with higher mortality rates observed in the lowest activity quartile (hazard ratio (HR)=2.18, 95% confidence interval (CI)=1.63-2.92) than in the highest quartile after adjusting for age, clinic site, race, body mass index, cognitive function, exercise, instrumental activity of daily living impairments, depression, medications, alcohol, smoking, self-reported health status, married status, and comorbidities. A greater risk of mortality from all causes was observed for those in the lowest quartiles of mesor (HR=1.71, 95% CI=1.29-2.27) and rhythm robustness (HR=1.97, 95% CI=1.50-2.60) than for those in the highest quartiles. Greater mortality from cancer (HR=2.09, 95% CI=1.04-4.22) and stroke (HR=2.64, 95% CI=1.11-6.30) was observed for later peak activity (after 4:33 p.m.; >1.5 SD from mean) than for the mean peak range (2:50-4:33 p.m.). CONCLUSION: Older women with weak circadian activity rhythms have higher mortality risk. If confirmed in other cohorts, studies will be needed to test whether interventions (e.g., physical activity, bright light exposure) that regulate circadian activity rhythms will improve health outcomes in older adults.
Authors: M C Mormont; J Waterhouse; P Bleuzen; S Giacchetti; A Jami; A Bogdan; J Lellouch; J L Misset; Y Touitou; F Lévi Journal: Clin Cancer Res Date: 2000-08 Impact factor: 12.531
Authors: J H Ficker; S H Dertinger; W Siegfried; H J König; M Pentz; D Sailer; A Katalinic; E G Hahn Journal: Eur Respir J Date: 1998-01 Impact factor: 16.671
Authors: Gregory J Tranah; Terri Blackwell; Katie L Stone; Sonia Ancoli-Israel; Misti L Paudel; Kristine E Ensrud; Jane A Cauley; Susan Redline; Teresa A Hillier; Steven R Cummings; Kristine Yaffe Journal: Ann Neurol Date: 2011-11 Impact factor: 10.422
Authors: Misti L Paudel; Brent C Taylor; Sonia Ancoli-Israel; Terri Blackwell; Katie L Stone; Greg Tranah; Susan Redline; Steven R Cummings; Kristine E Ensrud Journal: Chronobiol Int Date: 2010-01 Impact factor: 2.877
Authors: Qian Xiao; Jingyi Qian; Daniel S Evans; Susan Redline; Nancy E Lane; Sonia Ancoli-Israel; Frank A J L Scheer; Katie Stone Journal: Diabetes Care Date: 2020-09-04 Impact factor: 19.112
Authors: Andrea M Barsevick; Michael R Irwin; Pamela Hinds; Andrew Miller; Ann Berger; Paul Jacobsen; Sonia Ancoli-Israel; Bryce B Reeve; Karen Mustian; Ann O'Mara; Jin-Shei Lai; Michael Fisch; David Cella Journal: J Natl Cancer Inst Date: 2013-09-18 Impact factor: 13.506
Authors: Elizabeth E Devore; Stephanie L Harrison; Katie L Stone; Kathleen F Holton; Elizabeth Barrett-Connor; Sonia Ancoli-Israel; Kristine Yaffe; Kristine Ensrud; Peggy M Cawthon; Susan Redline; Eric Orwoll; Eva S Schernhammer Journal: Sleep Med Date: 2016-08-04 Impact factor: 3.492
Authors: Daniel S Evans; Neeta Parimi; Caroline M Nievergelt; Terri Blackwell; Susan Redline; Sonia Ancoli-Israel; Eric S Orwoll; Steven R Cummings; Katie L Stone; Gregory J Tranah Journal: Sleep Date: 2013-03-01 Impact factor: 5.849
Authors: Stephen F Smagula; Robert M Boudreau; Katie Stone; Charles F Reynolds; Joyce T Bromberger; Sonia Ancoli-Israel; Thuy-Tien Dam; Elizabeth Barrett-Connor; Jane A Cauley Journal: Chronobiol Int Date: 2015-11-23 Impact factor: 2.877