AIM: The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case-control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX). METHODS: In our case-control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age- and sex-matched control group results. RESULTS: Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (-0.34 +/- 0.97) and femur (-0.82 +/- 1.37) regions, compared to the control group (0.84 +/- 0.53 and 1.02 +/- 1.04 respectively; P-value = 0.000 and 0.000). CONCLUSION: The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.
AIM: The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case-control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX). METHODS: In our case-control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age- and sex-matched control group results. RESULTS: Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (-0.34 +/- 0.97) and femur (-0.82 +/- 1.37) regions, compared to the control group (0.84 +/- 0.53 and 1.02 +/- 1.04 respectively; P-value = 0.000 and 0.000). CONCLUSION: The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac Bpatients are prone to reduced bone density similar to severe hemophiliac A patients.
Authors: Junjiang Sun; Baolai Hua; Eric W Livingston; Sarah Taves; Peter B Johansen; Maureane Hoffman; Mirella Ezban; Dougald M Monroe; Ted A Bateman; Paul E Monahan Journal: Blood Date: 2016-12-30 Impact factor: 22.113
Authors: S A Paschou; P Anagnostis; S Karras; C Annweiler; S Vakalopoulou; V Garipidou; D G Goulis Journal: Osteoporos Int Date: 2014-07-08 Impact factor: 4.507
Authors: Sarah Taves; Junjiang Sun; Eric W Livingston; Xin Chen; Jerome Amiaud; Regis Brion; William B Hannah; Ted A Bateman; Dominique Heymann; Paul E Monahan Journal: Sci Rep Date: 2019-10-08 Impact factor: 4.379