Literature DB >> 20373028

Dendritic cell co-transfected with FasL and allergen genes induces T cell tolerance and decreases airway inflammation in allergen induced murine model.

Yan Wang1, Yutian Bi, Kui Wu, Changzheng Wang.   

Abstract

Dendritic cell (DC) displays tremendous functional plasticity in response to antigens and plays important roles in inducing immune tolerance. In this study, we investigated the effects of immature DC (imDC) co-transfected with FasL and allergen Der p2 genes (FasL-Der p2-DC) on inducing immune tolerance and modulating airway inflammation of Der p2-induced allergic mice. Moreover, we compared the effects of FasL-Der p2-DC with FasL-transfected imDC (FasL-DC) and Der p2-transfected imDC (Der p2-DC) respectively. Results showed that FasL-Der p2-DC and Der p2-pulsed FasL-DC induced T cell unresponsiveness to Der p2 via apoptosis. Der p2-DC could induce T cell hyporesponsiveness to Der p2. FasL-Der p2-DC, FasL-DC and Der p2-DC could inhibit Th2 response and reduce allergic airway inflammation. FasL-Der p2-DC was more effective than FasL-DC and Der p2-DC, respectively. These results demonstrate that FasL and allergen genes co-expressing DC might be a promising approach to allergy therapy.

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Year:  2010        PMID： 20373028     DOI： 10.1007/s11033-010-0170-7

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  25 in total

1.  An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.

Authors:  M B Lutz; N Kukutsch; A L Ogilvie; S Rössner; F Koch; N Romani; G Schuler
Journal:  J Immunol Methods       Date:  1999-02-01       Impact factor: 2.303

2.  Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells.

Authors:  H Matsue; K Matsue; M Walters; K Okumura; H Yagita; A Takashima
Journal:  Nat Med       Date:  1999-08       Impact factor: 53.440

3.  Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival.

Authors:  W P Min; R Gorczynski; X Y Huang; M Kushida; P Kim; M Obataki; J Lei; R M Suri; M S Cattral
Journal:  J Immunol       Date:  2000-01-01       Impact factor: 5.422

Review 4.  Induction of tolerance using Fas ligand: a double-edged immunomodulator.

Authors:  Nadir Askenasy; Esma S Yolcu; Isaac Yaniv; Haval Shirwan
Journal:  Blood       Date:  2004-10-14       Impact factor: 22.113

5.  Suppression of allergic inflammation by allergen-DNA-modified dendritic cells depends on the induction of Foxp3+ Regulatory T cells.

Authors:  Kui Wu; Yuttian Bi; Kun Sun; Junbo Xia; Yan Wang; Changzheng Wang
Journal:  Scand J Immunol       Date:  2008-02       Impact factor: 3.487

6.  Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma.

Authors:  D A Randolph; C J Carruthers; S J Szabo; K M Murphy; D D Chaplin
Journal:  J Immunol       Date:  1999-02-15       Impact factor: 5.422

7.  Fas inhibition attenuates lipopolysaccharide-induced apoptosis and cytokine release of rat type II alveolar epithelial cells.

Authors:  Xinhua Ma; Daomiao Xu; Yuhang Ai; Guangfeng Ming; Shuangping Zhao
Journal:  Mol Biol Rep       Date:  2009-10-13       Impact factor: 2.316

Review 8.  Allergic airway inflammation.

Authors:  Devendra K Agrawal; Arpita Bharadwaj
Journal:  Curr Allergy Asthma Rep       Date:  2005-03       Impact factor: 4.919

Review 9.  Dendritic cells as immune regulators: the mouse model.

Authors:  K L Griffiths; H C O'Neill
Journal:  J Cell Mol Med       Date:  2008-06-09       Impact factor: 5.310

10.  Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cells.

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Journal:  J Cell Mol Med       Date:  2008-04       Impact factor: 5.310
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  4 in total

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Journal:  Mol Biol Rep       Date:  2011-05-18       Impact factor: 2.316

2.  Kinetic and distinct distribution of conventional dendritic cells in the early phase of lipopolysaccharide-induced acute lung injury.

Authors:  Jun Liu; Peng-Shu Zhang; Qing Yu; Ling Liu; Yi Yang; Hai-Bo Qiu
Journal:  Mol Biol Rep       Date:  2012-10-08       Impact factor: 2.316

Review 3.  Treatment of allergic asthma: modulation of Th2 cells and their responses.

Authors:  Berislav Bosnjak; Barbara Stelzmueller; Klaus J Erb; Michelle M Epstein
Journal:  Respir Res       Date:  2011-08-25

4.  Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells.

Authors:  J L Ather; K A Fortner; R C Budd; V Anathy; M E Poynter
Journal:  Cell Death Dis       Date:  2013-09-05       Impact factor: 8.469
  4 in total

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