Literature DB >> 20372741

An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne.

Christian Spiteri1, Christopher Mason, Fengzhi Zhang, Dougal J Ritson, Pallavi Sharma, Steve Keeling, John E Moses.   

Abstract

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

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Year:  2010        PMID: 20372741     DOI: 10.1039/b927235f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

1.  Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity.

Authors:  Brian C Sanders; Frédéric Friscourt; Petr A Ledin; Ngalle Eric Mbua; Selvanathan Arumugam; Jun Guo; Thomas J Boltje; Vladimir V Popik; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2010-12-23       Impact factor: 15.419

2.  Aryl nitrile oxide cycloaddition reactions in the presence of pinacol boronic acid ester.

Authors:  Sarah L Harding; Sebastian M Marcuccio; G Paul Savage
Journal:  Beilstein J Org Chem       Date:  2012-04-19       Impact factor: 2.883

  2 in total

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