Literature DB >> 20371477

Engineered proteins pull double duty.

Jennifer R Cochran1.   

Abstract

Myriad bi-specific proteins have been developed that recognize two different clinical targets, with the goal of achieving enhanced therapeutic effects as compared with proteins that interact with only one target. These engineered proteins are starting to enter clinical testing for a variety of biomedical applications, particularly cancer treatment.

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Year:  2010        PMID： 20371477     DOI： 10.1126/scitranslmed.3000276

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  9 in total

1.  Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin.

Authors:  Niv Papo; Adam P Silverman; Jennifer L Lahti; Jennifer R Cochran
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-08       Impact factor: 11.205

2.  ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.

Authors:  Haiming Luo; Christopher G England; Shreya Goel; Stephen A Graves; Fanrong Ai; Bai Liu; Charles P Theuer; Hing C Wong; Robert J Nickles; Weibo Cai
Journal:  Mol Pharm       Date:  2017-03-24       Impact factor: 4.939

Review 3.  Strategies for protein synthetic biology.

Authors:  Raik Grünberg; Luis Serrano
Journal:  Nucleic Acids Res       Date:  2010-04-12       Impact factor: 16.971

4.  Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells.

Authors:  Alexander Eggel; Günther Baravalle; Gabriel Hobi; Beomkyu Kim; Patrick Buschor; Patrik Forrer; Jeoung-Sook Shin; Monique Vogel; Beda M Stadler; Clemens A Dahinden; Theodore S Jardetzky
Journal:  J Allergy Clin Immunol       Date:  2014-03-15       Impact factor: 10.793

5.  Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag.

Authors:  Jason E Hudak; Robyn M Barfield; Gregory W de Hart; Patricia Grob; Eva Nogales; Carolyn R Bertozzi; David Rabuka
Journal:  Angew Chem Int Ed Engl       Date:  2012-03-12       Impact factor: 15.336

6.  Multiplexed Targeting of Barrett's Neoplasia with a Heterobivalent Ligand: Imaging Study on Mouse Xenograft in Vivo and Human Specimens ex Vivo.

Authors:  Jing Chen; Juan Zhou; Zhenghong Gao; Xue Li; Fa Wang; Xiyu Duan; Gaoming Li; Bishnu P Joshi; Rork Kuick; Henry D Appelman; Thomas D Wang
Journal:  J Med Chem       Date:  2018-06-19       Impact factor: 7.446

7.  DNA-mediated assembly of protein heterodimers on membrane surfaces.

Authors:  Michael P Coyle; Qian Xu; Samantha Chiang; Matthew B Francis; Jay T Groves
Journal:  J Am Chem Soc       Date:  2013-03-26       Impact factor: 15.419

Review 8.  Design and applications of bispecific heterodimers: molecular imaging and beyond.

Authors:  Haiming Luo; Hao Hong; Sarah P Yang; Weibo Cai
Journal:  Mol Pharm       Date:  2014-04-28       Impact factor: 4.939

9.  Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions.

Authors:  Meng Liu; Azzurra Apriceno; Miguel Sipin; Edoardo Scarpa; Laura Rodriguez-Arco; Alessandro Poma; Gabriele Marchello; Giuseppe Battaglia; Stefano Angioletti-Uberti
Journal:  Nat Commun       Date:  2020-09-24       Impact factor: 14.919
  9 in total

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