Literature DB >> 2037079

Inhibition of electrical activity in mouse pancreatic beta-cells by the ATP/ADP translocase inhibitor, bongkrekic acid.

B Kiranadi1, J A Bangham, P A Smith.   

Abstract

Bongkrekic acid causes fatal food poisoning which is associated with hyperglycaemia. Here we demonstrate that bongkrekic acid, a potent inhibitor of the mitochondrial ATP/ADP translocase, inhibits glucose-induced electrical activity in the pancreatic beta-cell through the stimulation of ATP-sensitive potassium channel (K-ATP-channel) activity. By comparison of its effects with those of oligomycin, we suggest that bongkrekic acid acts by the inhibition of glucose metabolism and may induce hyperglycaemia by impairing beta-cell function.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 2037079     DOI： 10.1016/0014-5793(91)80561-g

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

Authors:  Chee Yeun Chung; Hyemyung Seo; Kai Christian Sonntag; Andrew Brooks; Ling Lin; Ole Isacson
Journal:  Hum Mol Genet       Date:  2005-05-11       Impact factor: 6.150

Review 2.  Metabolic cycles and signals for insulin secretion.

Authors:  Matthew J Merrins; Barbara E Corkey; Richard G Kibbey; Marc Prentki
Journal:  Cell Metab       Date:  2022-06-20       Impact factor: 31.373

3.  Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells.

Authors:  M R Duchen; P A Smith; F M Ashcroft
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

4.  Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to Identify Compounds That Alter Insulin Granule Dynamics.

Authors:  Na Young Yi; Qingping He; Thomas B Caligan; Ginger R Smith; Lawrence J Forsberg; Jay E Brenman; Jonathan Z Sexton
Journal:  Assay Drug Dev Technol       Date:  2015-10-27       Impact factor: 1.738

5.  Evidence of a role for GTP in the potentiation of Ca(2+)-induced insulin secretion by glucose in intact rat islets.

Authors:  M Meredith; M E Rabaglia; S A Metz
Journal:  J Clin Invest       Date:  1995-08       Impact factor: 14.808
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.