Literature DB >> 2037065

cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.

J L Benovic1, W C Stone, K Huebner, C Croce, M G Caron, R J Lefkowitz.   

Abstract

The beta-adrenergic receptor kinase (beta ARK) mediates agonist-dependent phosphorylation of the beta 2-adrenergic and related G protein-coupled receptors. A cDNA encoding bovine beta ARK has recently been isolated. In this work we have isolated a cDNA encoding human beta ARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine beta ARK. Chromosomal location of the human beta ARK gene was determined by correlating the presence of the beta ARK locus with retention of a specific human chromosome in a rodent-human hybrid panel. This analysis revealed that the human beta ARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.

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Year:  1991        PMID： 2037065     DOI： 10.1016/0014-5793(91)80568-n

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13.

Authors:  Y Gong; M Vikkula; L Boon; J Liu; P Beighton; R Ramesar; L Peltonen; H Somer; T Hirose; B Dallapiccola; A De Paepe; W Swoboda; B Zabel; A Superti-Furga; B Steinmann; H G Brunner; A Jans; R G Boles; W Adkins; M J van den Boogaard; B R Olsen; M L Warman
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

2.  Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

Authors:  R Winstel; S Freund; C Krasel; E Hoppe; M J Lohse
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-05       Impact factor: 11.205

3.  An autoregulatory region in protein kinase C: the pseudoanchoring site.

Authors:  D Ron; D Mochly-Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-17       Impact factor: 11.205

4.  GRK3 is essential for metastatic cells and promotes prostate tumor progression.

Authors:  Wenliang Li; Nanping Ai; Suming Wang; Nandita Bhattacharya; Vladimir Vrbanac; Michael Collins; Sabina Signoretti; Yanhui Hu; Frederick M Boyce; Karsten Gravdal; Ole J Halvorsen; Hawa Nalwoga; Lars A Akslen; Ed Harlow; Randolph S Watnick
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205

5.  Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.

Authors:  J T Pang; S E Lloyd; C Wooding; B Farren; B Pottinger; B Harding; S E Leigh; M A Pook; F J Benham; G T Gillett; R T Taggart; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

6.  Identification of additional members of human G-protein-coupled receptor kinase multigene family.

Authors:  B Haribabu; R Snyderman
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

7.  GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma.

Authors:  Yuan Li; Yibo Fan; Jinbang Xu; Longfei Huo; Ailing W Scott; Jiankang Jin; Boxuan Yang; Shan Shao; Lang Ma; Ying Wang; Xiaodan Yao; Melissa Pool Pizzi; Matheus Sewastjanow Da Silva; Guoliang Zhang; Lijuan Zhuo; Eun Jeong Cho; Kevin N Dalby; Namita D Shanbhag; Zhenning Wang; Wenliang Li; Shumei Song; Jaffer A Ajani
Journal:  J Exp Clin Cancer Res       Date:  2022-08-23
  7 in total

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