Literature DB >> 20370503

Search for mechanisms of exceptional human longevity.

Natalia S Gavrilova1, Leonid A Gavrilov.   

Abstract

This study presents initial findings of a new ongoing research project aimed to identify important predictors and mechanisms of exceptional human longevity. For this purpose the detailed data on long-lived people surviving to 100 years in the Unites States are collected, validated, and analyzed. The study found that being born to a young mother is an important predictor of person's longevity. The study also found that the "stout" body build at age 30 years (being in the heaviest 15% of population) significantly decreases chances of survival to 100 years. These findings demonstrate that early-life and mid-life personal characteristics play an important role in human longevity.

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Year:  2010        PMID: 20370503      PMCID: PMC2946054          DOI: 10.1089/rej.2009.0968

Source DB:  PubMed          Journal:  Rejuvenation Res        ISSN: 1549-1684            Impact factor:   4.663


  11 in total

1.  Maternal age and traits in offspring.

Authors:  M H Wang; F S vom Saal
Journal:  Nature       Date:  2000-09-28       Impact factor: 49.962

2.  Parental effects on offspring longevity--evidence from 17th to 19th century reproductive histories.

Authors:  Ariane Kemkes-Grottenthaler
Journal:  Ann Hum Biol       Date:  2004 Mar-Apr       Impact factor: 1.533

3.  Advanced maternal age--how old is too old?

Authors:  Linda J Heffner
Journal:  N Engl J Med       Date:  2004-11-04       Impact factor: 91.245

4.  Aging (not so) gracefully.

Authors:  Sharon E Bickel
Journal:  Nat Genet       Date:  2005-12       Impact factor: 38.330

5.  Maternal age at the birth of the first child as an epistatic factor in polygenic disorders.

Authors:  David E Comings; James P MacMurray
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2006-01-05       Impact factor: 3.568

6.  Is delayed childbearing changing gene frequencies in Western populations?

Authors:  E Gloria-Bottini; E Cosmi; M Nicotra; E V Cosmi; E Bottini
Journal:  Hum Biol       Date:  2005-08       Impact factor: 0.553

7.  Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women.

Authors:  David L Keefe; Sonia Franco; Lin Liu; James Trimarchi; Benning Cao; Sherry Weitzen; Shoba Agarwal; Maria A Blasco
Journal:  Am J Obstet Gynecol       Date:  2005-04       Impact factor: 8.661

8.  Delayed motherhood decreases life expectancy of mouse offspring.

Authors:  Juan J Tarín; Vanessa Gómez-Piquer; Francisco Rausell; Samuel Navarro; Carlos Hermenegildo; Antonio Cano
Journal:  Biol Reprod       Date:  2005-02-02       Impact factor: 4.285

Review 9.  Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytes.

Authors:  F Pellestor; T Anahory; S Hamamah
Journal:  Cytogenet Genome Res       Date:  2005       Impact factor: 1.636

10.  Long-term effects of delayed motherhood in mice on postnatal development and behavioural traits of offspring.

Authors:  Juan J Tarín; Vanessa Gómez-Piquer; Carmen Manzanedo; José Miñarro; Carlos Hermenegildo; Antonio Cano
Journal:  Hum Reprod       Date:  2003-08       Impact factor: 6.918

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  4 in total

1.  Comments on dietary restriction, Okinawa diet and longevity.

Authors:  Natalia S Gavrilova; Leonid A Gavrilov
Journal:  Gerontology       Date:  2011-08-31       Impact factor: 5.140

2.  A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging.

Authors:  Fabian Sanchis-Gomar; Helios Pareja-Galeano; Alejandro Santos-Lozano; Nuria Garatachea; Carmen Fiuza-Luces; Letizia Venturini; Giovanni Ricevuti; Alejandro Lucia; Enzo Emanuele
Journal:  Age (Dordr)       Date:  2015-04-25

3.  Contribution of obesity to international differences in life expectancy.

Authors:  Samuel H Preston; Andrew Stokes
Journal:  Am J Public Health       Date:  2011-09-22       Impact factor: 9.308

4.  New Developments in the Biodemography of Aging and Longevity.

Authors:  Leonid A Gavrilov; Natalia S Gavrilova
Journal:  Gerontology       Date:  2014-12-20       Impact factor: 5.140

  4 in total

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