Literature DB >> 20369184

One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N'-benzyl-N,N-dimethylureas.

Keith Smith1, Gamal A El-Hiti, Amany S Hegazy.   

Abstract

Lithiation of various N'-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 degrees C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

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Year:  2010        PMID： 20369184     DOI： 10.1039/b926983e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Synthesis of sulfur-containing heterocycles via ring enlargement.

Authors:  Bakr F Abdel-Wahab; Saad Shaaban; Gamal A El-Hiti
Journal:  Mol Divers       Date:  2018-01-31       Impact factor: 2.943

2.  Direct synthesis of arenecarboxamides through Friedel-Crafts acylation using ureas.

Authors:  Wenjiang Ying; Lalith S R Gamage; Luke R Lovro; James W Herndon; Nathan W Jenkins; James W Herndon
Journal:  Tetrahedron Lett       Date:  2014-08-13       Impact factor: 2.415

3.  A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.

Authors:  Keith Smith; Gamal A El-Hiti; Amany S Hegazy; Benson Kariuki
Journal:  Beilstein J Org Chem       Date:  2011-09-06       Impact factor: 2.883
  3 in total

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