Literature DB >> 2036805

Desferrioxamine ameliorates retinal photic injury in albino rats.

Z L Li1, S Lam, M O Tso.   

Abstract

Albino rats were given intraperitoneal desferrioxamine before exposure to intense fluorescent light. Morphometric and morphologic studies of the retina indicated that there was better preservation of photoreceptor nuclei and fewer subretinal macrophages in rats treated with desferrioxamine than in the control rats. The results of the study imply that iron and hydroxyl radicals may be important mediators in photic retinal injury.

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Year:  1991        PMID： 2036805     DOI： 10.3109/02713689109001741

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  13 in total

1.  Redox proteomic identification of visual arrestin dimerization in photoreceptor degeneration after photic injury.

Authors:  Christopher J Lieven; Jonathan D Ribich; Megan E Crowe; Leonard A Levin
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-26       Impact factor: 4.799

2.  Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.

Authors:  Majda Hadziahmetovic; Usha Kumar; Ying Song; Steven Grieco; Delu Song; Yafeng Li; John W Tobias; Joshua L Dunaief
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-08-07       Impact factor: 4.799

3.  Ironing out neurodegeneration: iron chelation for neuroprotection.

Authors:  Joshua L Dunaief
Journal:  Free Radic Biol Med       Date:  2011-05-14       Impact factor: 7.376

4.  Curcumin protects retinal cells from light-and oxidant stress-induced cell death.

Authors:  Md Nawajes A Mandal; Jagan M R Patlolla; Lixin Zheng; Martin-Paul Agbaga; Julie-Thu A Tran; Lea Wicker; Anne Kasus-Jacobi; Michael H Elliott; Chinthalapally V Rao; Robert E Anderson
Journal:  Free Radic Biol Med       Date:  2008-12-24       Impact factor: 7.376

5.  Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism.

Authors:  Ignacio R Rodriguez; Steven J Fliesler
Journal:  Photochem Photobiol       Date:  2009-05-20       Impact factor: 3.421

6.  Damage to cultured lens epithelial cells of squirrels and rabbits by UV-A (99.9%) plus UV-B (0.1%) radiation and alpha tocopherol protection.

Authors:  S Zigman; T McDaniel; J B Schultz; J Reddan; M Meydani
Journal:  Mol Cell Biochem       Date:  1995-02-09       Impact factor: 3.396

7.  Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina.

Authors:  Delu Song; Ying Song; Majda Hadziahmetovic; Yong Zhong; Joshua L Dunaief
Journal:  Free Radic Biol Med       Date:  2012-05-01       Impact factor: 7.376

8.  Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage.

Authors:  James Randazzo; Zifeng Zhang; Michael Hoff; Hiroyoshi Kawada; Andrew Sachs; Yang Yuan; Neena Haider; Peter Kador
Journal:  PLoS One       Date:  2011-07-14       Impact factor: 3.240

9.  The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.

Authors:  Majda Hadziahmetovic; Miroslav Pajic; Steven Grieco; Ying Song; Delu Song; Yafeng Li; Alyssa Cwanger; Jared Iacovelli; Sally Chu; Gui-Shuang Ying; John Connelly; Michael Spino; Joshua L Dunaief
Journal:  Transl Vis Sci Technol       Date:  2012-09-28       Impact factor: 3.283

10.  The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms.

Authors:  Majda Hadziahmetovic; Miroslav Pajic; Steven Grieco; Ying Song; Delu Song; Yafeng Li; Alyssa Cwanger; Jared Iacovelli; Sally Chu; Gui-Shuang Ying; John Connelly; Michael Spino; Joshua L Dunaief
Journal:  Transl Vis Sci Technol       Date:  2012-10-25       Impact factor: 3.283
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