| Literature DB >> 20367601 |
E Y Plotnikov1, D N Silachev, A A Chupyrkina, M I Danshina, S S Jankauskas, M A Morosanova, E V Stelmashook, A K Vasileva, E S Goryacheva, Y A Pirogov, N K Isaev, D B Zorov.
Abstract
A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6'-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. Control substance not containing plastoquinone appeared to be not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.Entities:
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Year: 2010 PMID： 20367601 DOI： 10.1134/s0006297910020045
Source DB: PubMed Journal: Biochemistry (Mosc) ISSN： 0006-2979 Impact factor: 2.487