BACKGROUND: Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MSSA and MRSA, respectively) are both associated with severe infections, such as necrotizing pneumonia. The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available. OBJECTIVES: The objectives of the study were to investigate the global population structure of PVL-positive MSSA, to compare it with that reported for CA-MRSA, and thus to examine the phylogenetic relationship between these pathogens. METHODS: We determined the agr types, multilocus sequence types, and toxin gene profiles of 211 PVL-positive MSSA clinical isolates collected in 19 countries throughout the world between 1981 and 2007. RESULTS: The predominant lineages of PVL-positive MSSA were agr3/ST30, agr4/ST121, agr3/ST1, agr2/ST5, and agr3/ST80. Except for agr4/ST121, these lineages are also reported to be prevalent among CA-MRSA. PVL-positive MSSA lineages that are genetically related to CA-MRSA have gradually replaced other lineages (especially agr4/ST121) over the past 2 decades. Within a given sequence type, the toxin gene content of PVL-positive MSSA strains was very similar to that of PVL-positive CA-MRSA. CONCLUSIONS: The molecular epidemiological profiles of PVL-positive MSSA and CA-MRSA are dynamically interrelated, with the former appearing to constitute a reservoir for the latter.
BACKGROUND: Panton-Valentine leukocidin (PVL)-positive methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus (MSSA and MRSA, respectively) are both associated with severe infections, such as necrotizing pneumonia. The epidemiological profile of PVL-positive community-acquired (CA) MRSA has been extensively studied, but few corresponding data on PVL-positive MSSA are available. OBJECTIVES: The objectives of the study were to investigate the global population structure of PVL-positive MSSA, to compare it with that reported for CA-MRSA, and thus to examine the phylogenetic relationship between these pathogens. METHODS: We determined the agr types, multilocus sequence types, and toxin gene profiles of 211 PVL-positive MSSA clinical isolates collected in 19 countries throughout the world between 1981 and 2007. RESULTS: The predominant lineages of PVL-positive MSSA were agr3/ST30, agr4/ST121, agr3/ST1, agr2/ST5, and agr3/ST80. Except for agr4/ST121, these lineages are also reported to be prevalent among CA-MRSA. PVL-positive MSSA lineages that are genetically related to CA-MRSA have gradually replaced other lineages (especially agr4/ST121) over the past 2 decades. Within a given sequence type, the toxin gene content of PVL-positive MSSA strains was very similar to that of PVL-positive CA-MRSA. CONCLUSIONS: The molecular epidemiological profiles of PVL-positive MSSA and CA-MRSA are dynamically interrelated, with the former appearing to constitute a reservoir for the latter.
Authors: Kerry R Leedom Larson; Abby L Harper; Blake M Hanson; Michael J Male; Shylo E Wardyn; Anne E Dressler; Elizabeth A Wagstrom; Shaliesh Tendolkar; Daniel J Diekema; Kelley J Donham; Tara C Smith Journal: Appl Environ Microbiol Date: 2010-11-19 Impact factor: 4.792
Authors: K Ben Slama; H Gharsa; N Klibi; A Jouini; C Lozano; E Gómez-Sanz; M Zarazaga; A Boudabous; C Torres Journal: Eur J Clin Microbiol Infect Dis Date: 2010-11-11 Impact factor: 3.267
Authors: T Conceição; M Aires-de-Sousa; N Pona; M J Brito; C Barradas; R Coelho; T Sardinha; L Sancho; G de Sousa; M do Céu Machado; H de Lencastre Journal: Eur J Clin Microbiol Infect Dis Date: 2010-11-03 Impact factor: 3.267
Authors: S Madzgalla; M A Syed; M A Khan; S S Rehman; E Müller; A Reissig; R Ehricht; S Monecke Journal: Eur J Clin Microbiol Infect Dis Date: 2016-06-04 Impact factor: 3.267
Authors: M A M Huson; R Kalkman; J Remppis; J O Beyeme; C Kraef; F Schaumburg; A S Alabi; M P Grobusch Journal: Infection Date: 2014-01-25 Impact factor: 3.553