PURPOSE: To clarify the safety and feasibility of a 6-day protocol of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with intensive occupational therapy (OT) for upper limb hemiparesis. METHODS: In-hospital combination treatment was provided for 5 post-stroke patients with upper limb hemiparesis after more than 12 months of the onset of stroke. Over 6 consecutive days, each patient received 10 sessions of combination treatment with 1 Hz rTMS and intensive OT (one-on-one training and self-training). Motor function in the affected upper limb was evaluated by Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), Ten-Second Test at admission, discharge, and 4 weeks after treatment. RESULTS: All patients completed the 6-day treatment protocol and none showed any adverse effects throughout the treatment. At the end of treatment, improvements in the scores of FMA, WMFT, and Ten-Second Test were found in all patients. No deterioration of improved upper limb function was observed at 4 weeks after the treatment. CONCLUSIONS: Our proposed protocol of combination treatment seems to be safe and feasible for post-stroke patients with upper limb hemiparesis, although the efficacy of the protocol needs to be confirmed in a large number of patients.
PURPOSE: To clarify the safety and feasibility of a 6-day protocol of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with intensive occupational therapy (OT) for upper limb hemiparesis. METHODS: In-hospital combination treatment was provided for 5 post-strokepatients with upper limb hemiparesis after more than 12 months of the onset of stroke. Over 6 consecutive days, each patient received 10 sessions of combination treatment with 1 Hz rTMS and intensive OT (one-on-one training and self-training). Motor function in the affected upper limb was evaluated by Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), Ten-Second Test at admission, discharge, and 4 weeks after treatment. RESULTS: All patients completed the 6-day treatment protocol and none showed any adverse effects throughout the treatment. At the end of treatment, improvements in the scores of FMA, WMFT, and Ten-Second Test were found in all patients. No deterioration of improved upper limb function was observed at 4 weeks after the treatment. CONCLUSIONS: Our proposed protocol of combination treatment seems to be safe and feasible for post-strokepatients with upper limb hemiparesis, although the efficacy of the protocol needs to be confirmed in a large number of patients.
Authors: Adriana B Conforto; Sarah M Anjos; Gustavo Saposnik; Eduardo A Mello; Erina M Nagaya; Waldyr Santos; Karina N Ferreiro; Eduardo S Melo; Felipe I Reis; Milberto Scaff; Leonardo G Cohen Journal: J Neurol Date: 2011-12-16 Impact factor: 4.849
Authors: Ela B Plow; David A Cunningham; Erik Beall; Stephen Jones; Alexandria Wyant; Corin Bonnett; Guang H Yue; Mark Lowe; Xiao-Feng Wang; Ken Sakaie; Andre Machado Journal: Trials Date: 2013-10-12 Impact factor: 2.279