Csaba Varga1, Katalin Szendi. 1. Department of Environmental Health, Institute of Public Health Medicine, University of Pécs, Pécs, 7624 Hungary.
Abstract
BACKGROUND: Different types of carbon nanotubes may represent toxic hazards due to their size distribution and massive surface area. They may adsorb other toxic agents that can consequently be transported into the body. Hence the aim of this study was to confirm or reject the hypothesis of carcinogenicity of two types of carbon nanotubes. MATERIALS AND METHODS: Well-defined single-walled and multi-walled carbon nanotubes were studied in a specific animal model for mesothelioma induction. RESULTS: Short-term pilot studies were published on the asbestos fibre-like mesothelioma-inducing effects of carbon nanotubes based on the proposed mechanistic correlation on health effects of fibres of the same size. Our results with a simple in vivo, peritoneal exposure model refute such an interpretation. The present studies with rats indicate that early granuloma formation does not lead to the development of mesotheliomas during chronic exposure of peritoneal mesothelium to either single- or multi-walled carbon nanotubes of varied size. CONCLUSION: Due to the limited toxicity data on carbon nanotubes, these results may be particularly important for risk assessment purposes.
BACKGROUND: Different types of carbon nanotubes may represent toxic hazards due to their size distribution and massive surface area. They may adsorb other toxic agents that can consequently be transported into the body. Hence the aim of this study was to confirm or reject the hypothesis of carcinogenicity of two types of carbon nanotubes. MATERIALS AND METHODS: Well-defined single-walled and multi-walled carbon nanotubes were studied in a specific animal model for mesothelioma induction. RESULTS: Short-term pilot studies were published on the asbestos fibre-like mesothelioma-inducing effects of carbon nanotubes based on the proposed mechanistic correlation on health effects of fibres of the same size. Our results with a simple in vivo, peritoneal exposure model refute such an interpretation. The present studies with rats indicate that early granuloma formation does not lead to the development of mesotheliomas during chronic exposure of peritoneal mesothelium to either single- or multi-walled carbon nanotubes of varied size. CONCLUSION: Due to the limited toxicity data on carbon nanotubes, these results may be particularly important for risk assessment purposes.
Authors: Xinyuan Liu; Sujat Sen; Jingyu Liu; Indrek Kulaots; David Geohegan; Agnes Kane; Alex A Puretzky; Christopher M Rouleau; Karren L More; G Tayhas R Palmore; Robert H Hurt Journal: Small Date: 2011-08-05 Impact factor: 13.281
Authors: Eileen D Kuempel; Marie-Claude Jaurand; Peter Møller; Yasuo Morimoto; Norihiro Kobayashi; Kent E Pinkerton; Linda M Sargent; Roel C H Vermeulen; Bice Fubini; Agnes B Kane Journal: Crit Rev Toxicol Date: 2016-08-18 Impact factor: 5.635
Authors: Adriana Albini; Arianna Pagani; Laura Pulze; Antonino Bruno; Elisa Principi; Terenzio Congiu; Elisabetta Gini; Annalisa Grimaldi; Barbara Bassani; Silvio De Flora; Magda de Eguileor; Douglas M Noonan Journal: Int J Nanomedicine Date: 2015-09-29